| Texto completo | |
| Autor(es): Mostrar menos - |
Galasso, Marcos
[1]
;
Feld, Jordan J.
[2]
;
Watanabe, Yui
[1]
;
Pipkin, Mauricio
[1]
;
Summers, Cara
[1]
;
Ali, Aadil
[1]
;
Qaqish, Robert
[1]
;
Chen, Manyin
[1]
;
Ribeiro, Rafaela V. P.
[1]
;
Ramadan, Khaled
[1]
;
Pires, Layla
[1]
;
Bagnato, Vanderlei S.
[3]
;
Kurachi, Cristina
[3]
;
Cherepanov, Vera
[2]
;
Moonen, Gray
[1]
;
Gazzalle, Anajara
[1]
;
Waddell, Thomas K.
[1]
;
Liu, Mingyao
[1]
;
Keshavjee, Shaf
[1]
;
Wilson, Brian C.
[4]
;
Humar, Atul
[5]
;
Cypel, Marcelo
[1, 5]
Número total de Autores: 22
|
| Afiliação do(s) autor(es): | [1] Univ Hlth Network, Toronto Gen Res Inst, Latner Thorac Surg Res Labs, Toronto, ON M5G 2C4 - Canada
[2] Univ Hlth Network, Toronto Gen Hosp, Toronto Ctr Liver Dis, Toronto, ON M5G 2C4 - Canada
[3] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Paulo - Brazil
[4] Univ Toronto, Dept Med Biophys, Princess Margaret Canc Ctr, Toronto, ON M5G 2C4 - Canada
[5] Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON M5G 2C4 - Canada
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURE COMMUNICATIONS; v. 10, JAN 29 2019. |
| Citações Web of Science: | 12 |
| Resumo | |
Availability of organs is a limiting factor for lung transplantation, leading to substantial mortality rates on the wait list. Use of organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), would increase organ donation, but these organs are generally not offered for transplantation due to a high risk of transmission. Here, we develop a method for treatment of HCV-infected human donor lungs that prevents HCV transmission. Physical viral clearance in combination with germicidal light-based therapies during normothermic ex-vivo Lung Perfusion (EVLP), a method for assessment and treatment of injured donor lungs, inactivates HCV virus in a short period of time. Such treatment is shown to be safe using a large animal EVLP-to-lung transplantation model. This strategy of treating viral infection in a donor organ during preservation could significantly increase the availability of organs for transplantation and encourages further clinical development. (AU) | |
| Processo FAPESP: | 14/50857-8 - Inct 2014 - de optica basica e aplicada as ciencias da vida. |
| Beneficiário: | Vanderlei Salvador Bagnato |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica |
| Beneficiário: | Vanderlei Salvador Bagnato |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |