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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion

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Autor(es):
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Galasso, Marcos [1] ; Feld, Jordan J. [2] ; Watanabe, Yui [1] ; Pipkin, Mauricio [1] ; Summers, Cara [1] ; Ali, Aadil [1] ; Qaqish, Robert [1] ; Chen, Manyin [1] ; Ribeiro, Rafaela V. P. [1] ; Ramadan, Khaled [1] ; Pires, Layla [1] ; Bagnato, Vanderlei S. [3] ; Kurachi, Cristina [3] ; Cherepanov, Vera [2] ; Moonen, Gray [1] ; Gazzalle, Anajara [1] ; Waddell, Thomas K. [1] ; Liu, Mingyao [1] ; Keshavjee, Shaf [1] ; Wilson, Brian C. [4] ; Humar, Atul [5] ; Cypel, Marcelo [1, 5]
Número total de Autores: 22
Afiliação do(s) autor(es):
[1] Univ Hlth Network, Toronto Gen Res Inst, Latner Thorac Surg Res Labs, Toronto, ON M5G 2C4 - Canada
[2] Univ Hlth Network, Toronto Gen Hosp, Toronto Ctr Liver Dis, Toronto, ON M5G 2C4 - Canada
[3] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Paulo - Brazil
[4] Univ Toronto, Dept Med Biophys, Princess Margaret Canc Ctr, Toronto, ON M5G 2C4 - Canada
[5] Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON M5G 2C4 - Canada
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: NATURE COMMUNICATIONS; v. 10, JAN 29 2019.
Citações Web of Science: 12
Resumo

Availability of organs is a limiting factor for lung transplantation, leading to substantial mortality rates on the wait list. Use of organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), would increase organ donation, but these organs are generally not offered for transplantation due to a high risk of transmission. Here, we develop a method for treatment of HCV-infected human donor lungs that prevents HCV transmission. Physical viral clearance in combination with germicidal light-based therapies during normothermic ex-vivo Lung Perfusion (EVLP), a method for assessment and treatment of injured donor lungs, inactivates HCV virus in a short period of time. Such treatment is shown to be safe using a large animal EVLP-to-lung transplantation model. This strategy of treating viral infection in a donor organ during preservation could significantly increase the availability of organs for transplantation and encourages further clinical development. (AU)

Processo FAPESP: 14/50857-8 - INCT 2014 - de Óptica Básica e Aplicada às Ciências da Vida
Beneficiário:Vanderlei Salvador Bagnato
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
Beneficiário:Vanderlei Salvador Bagnato
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs