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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion

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Author(s):
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Galasso, Marcos [1] ; Feld, Jordan J. [2] ; Watanabe, Yui [1] ; Pipkin, Mauricio [1] ; Summers, Cara [1] ; Ali, Aadil [1] ; Qaqish, Robert [1] ; Chen, Manyin [1] ; Ribeiro, Rafaela V. P. [1] ; Ramadan, Khaled [1] ; Pires, Layla [1] ; Bagnato, Vanderlei S. [3] ; Kurachi, Cristina [3] ; Cherepanov, Vera [2] ; Moonen, Gray [1] ; Gazzalle, Anajara [1] ; Waddell, Thomas K. [1] ; Liu, Mingyao [1] ; Keshavjee, Shaf [1] ; Wilson, Brian C. [4] ; Humar, Atul [5] ; Cypel, Marcelo [1, 5]
Total Authors: 22
Affiliation:
[1] Univ Hlth Network, Toronto Gen Res Inst, Latner Thorac Surg Res Labs, Toronto, ON M5G 2C4 - Canada
[2] Univ Hlth Network, Toronto Gen Hosp, Toronto Ctr Liver Dis, Toronto, ON M5G 2C4 - Canada
[3] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Paulo - Brazil
[4] Univ Toronto, Dept Med Biophys, Princess Margaret Canc Ctr, Toronto, ON M5G 2C4 - Canada
[5] Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON M5G 2C4 - Canada
Total Affiliations: 5
Document type: Journal article
Source: NATURE COMMUNICATIONS; v. 10, JAN 29 2019.
Web of Science Citations: 12
Abstract

Availability of organs is a limiting factor for lung transplantation, leading to substantial mortality rates on the wait list. Use of organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), would increase organ donation, but these organs are generally not offered for transplantation due to a high risk of transmission. Here, we develop a method for treatment of HCV-infected human donor lungs that prevents HCV transmission. Physical viral clearance in combination with germicidal light-based therapies during normothermic ex-vivo Lung Perfusion (EVLP), a method for assessment and treatment of injured donor lungs, inactivates HCV virus in a short period of time. Such treatment is shown to be safe using a large animal EVLP-to-lung transplantation model. This strategy of treating viral infection in a donor organ during preservation could significantly increase the availability of organs for transplantation and encourages further clinical development. (AU)

FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC