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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The biotechnological potential of Epicoccum spp.: diversity of secondary metabolites

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Autor(es):
Braga, Raissa Mesquita [1] ; Padilla, Gabriel [1] ; Araujo, Welington Luiz [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, NAP BIOP LABMEM, Av Prof Lineu Prestes, 1374 Ed Biomed 2, BR-05508900 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: CRITICAL REVIEWS IN MICROBIOLOGY; v. 44, n. 6, p. 759-778, 2018.
Citações Web of Science: 1
Resumo

Epicoccum is a genus of ubiquitous fungi typically found in air, in soil, and on decaying vegetation. They also commonly display an endophytic lifestyle and are isolated from diverse plant tissues. The fungi from the genus Epicoccum are mainly known for their use as biocontrol agents against phytopathogens and for their ability to produce many secondary metabolites with potential biotechnological applications, such as antioxidant, anticancer, r and antimicrobial compounds. Among the bioactive compounds produced by Epicoccum spp., epicocconone is a commercially available fluorophore, D8646-2-6 is a patented telomerase inhibitor, and taxol is an anticancer drug originally isolated from Taxus brevifolia. Epicoccum spp. also produces epicolactone, an antimicrobial compound with a unique and complex structure that has aroused considerable interest in the chemical-synthesis community. The main goal of the present review is to discuss the diversity of secondary metabolites produced by Epicoccum spp., their biotechnological applications, and proposed hypothetical biosynthesis. In addition, the use of Epicoccum spp. as biocontrol agents and the pigments produced by these fungi are also discussed. (AU)

Processo FAPESP: 15/11563-1 - Mecanismos moleculares envolvidos na interação entre micro-organismos endofíticos e a planta hospedeira
Beneficiário:Welington Luiz de Araújo
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 17/12510-4 - Micro-organismos endofíticos e a planta hospedeira: genes e metabólitos envolvidos na interação
Beneficiário:Welington Luiz de Araújo
Modalidade de apoio: Auxílio à Pesquisa - Regular