Recent advances in the use of carbon nanotubes as smart biomaterials

Autor(es)

Canuto de Menezes, Beatriz Rossi ^[1] ; Rodrigues, Karla Faquine ^[1] ; da Silva Fonseca, Beatriz Carvalho ^[1] ; Ribas, Renata Guimaraes ^[1] ; do Amaral Montanheiro, Thais Larissa ^[1] ; Thim, Gilmar Patrocinio ^[1]

Afiliação do(s) autor(es)

^[1] ITA, Div Ciencias Fundamentais, Praca Marechal Eduardo Gomes 50, BR-12228970 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF MATERIALS CHEMISTRY B; v. 7, n. 9, p. 1343-1360, MAR 7 2019.
• Citações Web of Science: 9

Resumo

Carbon nanotubes (CNTs) have remarkable mechanical, thermal, electronic, and biological properties due to their particular atomic structure made of graphene sheets that are rolled into cylindrical tubes. Due to their outstanding properties, CNTs have been used in several technological fields. Currently, the most prominent research area of CNTs focuses on biomedical applications, using these materials to produce hybrid biosensors, drug delivery systems, and high performance composites for implants. Although a great number of research studies have already shown the advantages of CNT- based biomedical devices, their clinical use for in vivo application has not been consummated. Concerns related to their toxicity, biosafety, and biodegradation still remain. The effect of CNTs on the human body and the ecosystem is not well established, especially due to the lack of standardization of toxicological tests, which generate contradictions in the results. CNTs' toxicity must be clarified to enable the medical use of these exceptional materials in the near future. In this review, we summarize recent advances in developing biosensors, drug delivery systems, and implants using CNTs as smart biomaterials to identify pathogens, load/ deliver drugs and enhance the mechanical and antimicrobial performance of implants. (AU)

• Processo FAPESP: 17/24873-4 - Nanocompósito de PHBV e NTC funcionalizado com hidroxibutirato: estudo cinético da cristalização e correlação com as propriedades mecânicas
• Beneficiário: Thaís Larissa do Amaral Montanheiro
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/17492-6 - Efeito da funcionalização de CNTs com alcanos de diversos tamanhos nas propriedades do nanocompósito CNT/PEAD
• Beneficiário: Gilmar Patrocínio Thim
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/02846-5 - Nanocompósito AgVO3/PMMA: Efeito da funcionalização com acrilamida nas propriedades mecânicas e antimicrobianas
• Beneficiário: Beatriz Rossi Canuto de Menezes Rodrigues
• Linha de fomento: Bolsas no Brasil - Doutorado