Benzimidazoles in wastewater: Analytical method development, monitoring and degradation by photolysis and ozonation

Autor(es)

Porto, Rafael Silveira ^[1] ; Rodrigues-Silva, Caio ^[1] ; Schneider, Jerusa ^[2] ; Rath, Susanne ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Analyt Chem, Inst Chem, POB 6154, BR-13084971 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Civil Engn Architecture & Urban Design, POB 6143, BR-13083889 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Environmental Management; v. 232, p. 729-737, FEB 15 2019.
• Citações Web of Science: 1

Resumo

Pharmaceutical residues are constantly released into natural waters, mainly from wastewater treatment plants (WWTPs) whose processes are unable to completely eliminate them. Among these drugs, the occurrence of benzimidazoles, a class of antiparasitics for human and veterinary use, has been reported in WWTP effluents and surface waters. In this study, an SPE-UHPLC-MS/MS method was developed and optimized for extraction and quantitation of benzimidazoles in influents and effluents of a local WWTP and in hospital wastewater. The extraction procedure was optimized using response surface methodology (Box-Behnken design) and the optimal parameters were as follows: 2.0 mL of loading solvent consisting of a mixture of water:methanol (95:5, v/v) and temperature at 43 degrees C. In hospital wastewater, albendazole (ABZ) and its principal metabolite ricobendazole (RBZ) were the main benzimidazole-related contaminants and were found at concentrations of up to 3810 and 3894 ng L-1, respectively. The WWTP system was able to remove from 46% to 95% of the ABZ quantified in the influent, discharging an effluent with 16-441 ng L-1 of ABZ. The concentrations of other benzimidazoles and metabolites in the WWTP effluents remained below 350 ng L-1. WWTP effluents fortified with 50 mu g L-1 of ABZ required 26.7 mg(o3) L-1 to remove ABZ and RBZ. After ozonation, the COD and BOD5 of the effluents were reduced by 27%. Photolysis by UVA radiation was not effective to remove ABZ and FBZ from the effluent samples. (AU)

• Processo FAPESP: 13/09543-7 - Resíduos de medicamentos veterinários no ambiente
• Beneficiário: Susanne Rath
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/16622-3 - Identificação dos intermediários formados durante a degradação de fármacos veterinários por processos oxidativos avançados
• Beneficiário: Caio Alexandre Augusto Rodrigues da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50951-4 - INCT 2014: Tecnologias Analíticas Avançadas
• Beneficiário: Celio Pasquini
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/03571-2 - Fármacos no Ecossistema Aquático
• Beneficiário: Susanne Rath
• Modalidade de apoio: Auxílio à Pesquisa - Regular