| Texto completo | |
| Autor(es): |
Ishikawa, Debora T.
[1]
;
Lillo Vizin, Robson Cristiano
[1, 2]
;
de Souza, Cristiane Oliveira
[1]
;
Carrettiero, Daniel Carneiro
[1, 3]
;
Romanovsky, Andrej A.
[2]
;
Almeida, Maria Camila
[1, 3]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Fed Univ ABC, Grad Program Neurosci & Cognit, BR-09606070 Sao Bernardo Do Campo, SP - Brazil
[2] St Josephs Hosp, Thermoregulat & System Inflammat Lab, FeverLab, Phoenix, AZ 85013 - USA
[3] Fed Univ ABC, Ctr Nat & Human Sci, BR-09606070 Sao Bernardo Do Campo, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PHARMACEUTICALS; v. 12, n. 1 FEB 2 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Thermoregulatory grooming, a behavioral defense against heat, is known to be driven by skin-temperature signals. Because at least some thermal cutaneous signals that drive heat defenses are likely to be generated by transient receptor potential (TRP) channels, we hypothesized that warmth-sensitive TRPs drive thermoregulatory grooming. Adult male Wistar rats were used. We showed that camphor, a nonselective agonist of several TRP channels, including vanilloid (V) 3, when applied epidermally to the back (500 mg/kg), caused a pronounced self-grooming response, including paw-licking and snout- and chest-{''}washing{''}. By the percentage of time spent grooming, the response was similar to the thermoregulatory grooming observed during exposure to ambient warmth (32 degrees C). Ruthenium red (a non-selective antagonist of TRP channels, including TRPV3), when administered intravenously at a dose of 0.1 mg/kg, attenuated the self-grooming behavior induced by either ambient warmth or epidermal camphor. Furthermore, the intravenous administration of AMG8432 (40 mg/kg), a relatively selective TRPV3 antagonist, also attenuated the self-grooming response to epidermal camphor. We conclude that camphor causes the self-grooming behavior by acting on TRP channels in the skin. We propose that cutaneous warmth signals mediated by TRP channels, possibly including TRPV3, drive thermoregulatory self-grooming in rats. (AU) | |
| Processo FAPESP: | 13/25503-5 - Envolvimento dos canais TRPM8 na termorregulação de ratos Wistar |
| Beneficiário: | Robson Cristiano Lillo Vizin |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 15/23426-9 - Beta amiloide na patologia de Alzheimer: morte ou sobrevivência? Envolvimento da via NF-kappaB e BAG2 |
| Beneficiário: | Daniel Carneiro Carrettiero |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/02991-0 - Envolvimento dos canais TRPM8 na termorregulação de ratos Wistar |
| Beneficiário: | Maria Camila Almeida |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |