| Full text | |
| Author(s): |
Ishikawa, Debora T.
[1]
;
Lillo Vizin, Robson Cristiano
[1, 2]
;
de Souza, Cristiane Oliveira
[1]
;
Carrettiero, Daniel Carneiro
[1, 3]
;
Romanovsky, Andrej A.
[2]
;
Almeida, Maria Camila
[1, 3]
Total Authors: 6
|
| Affiliation: | [1] Fed Univ ABC, Grad Program Neurosci & Cognit, BR-09606070 Sao Bernardo Do Campo, SP - Brazil
[2] St Josephs Hosp, Thermoregulat & System Inflammat Lab, FeverLab, Phoenix, AZ 85013 - USA
[3] Fed Univ ABC, Ctr Nat & Human Sci, BR-09606070 Sao Bernardo Do Campo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | PHARMACEUTICALS; v. 12, n. 1 FEB 2 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Thermoregulatory grooming, a behavioral defense against heat, is known to be driven by skin-temperature signals. Because at least some thermal cutaneous signals that drive heat defenses are likely to be generated by transient receptor potential (TRP) channels, we hypothesized that warmth-sensitive TRPs drive thermoregulatory grooming. Adult male Wistar rats were used. We showed that camphor, a nonselective agonist of several TRP channels, including vanilloid (V) 3, when applied epidermally to the back (500 mg/kg), caused a pronounced self-grooming response, including paw-licking and snout- and chest-{''}washing{''}. By the percentage of time spent grooming, the response was similar to the thermoregulatory grooming observed during exposure to ambient warmth (32 degrees C). Ruthenium red (a non-selective antagonist of TRP channels, including TRPV3), when administered intravenously at a dose of 0.1 mg/kg, attenuated the self-grooming behavior induced by either ambient warmth or epidermal camphor. Furthermore, the intravenous administration of AMG8432 (40 mg/kg), a relatively selective TRPV3 antagonist, also attenuated the self-grooming response to epidermal camphor. We conclude that camphor causes the self-grooming behavior by acting on TRP channels in the skin. We propose that cutaneous warmth signals mediated by TRP channels, possibly including TRPV3, drive thermoregulatory self-grooming in rats. (AU) | |
| FAPESP's process: | 13/25503-5 - Involvement of TRPM8 channels in thermoregulation of Wistar rats |
| Grantee: | Robson Cristiano Lillo Vizin |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/23426-9 - Beta-amyloid in Alzheimer's Disease: death or survival? Involvement of NF-kappaB and BAG2 |
| Grantee: | Daniel Carneiro Carrettiero |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/02991-0 - Involvement of TRPM8 channels in thermoregulation of Wistar rats |
| Grantee: | Maria Camila Almeida |
| Support Opportunities: | Regular Research Grants |