Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis

Autor(es)

Rodrigues Gusman, David Jonathan ^{[1, 2]} ; Ervolino, Edilson ^[3] ; Theodoro, Leticia Helena ^[1] ; Garcia, Valdir Gouveia ^[1] ; Hitomi Nagata, Maria Jose ^[1] ; Sendao Alves, Breno Edson ^{[1, 4]} ; de Araujo, Nathalia Januario ^[1] ; Matheus, Henrique Rinaldi ^[1] ; de Almeida, Juliano Milanezi ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Dept Surg & Integrated Clin, Div Periodont, Sch Dent, Aracatuba, SP - Brazil

^[2] Univ Western Sao Paulo, UNOESTE, Dept Periodont, Presidente Prudente, SP - Brazil

^[3] Sao Paulo State Univ, UNESP, Sch Dent, Dept Basic Sci, Aracatuba, SP - Brazil

^[4] Maringa Univ Ctr, UNINGA, Dept Periodont, Maringa, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 46, n. 4, p. 457-469, APR 2019.
• Citações Web of Science: 0

Resumo

Aim This study evaluated the effects of 5-fluorouracil (5-FU) and cisplatin (CIS) in healthy periodontal tissues and in the early stages of experimental periodontitis (EP) in rats. Methods One hundred and eighty male rats were divided into three groups, which were submitted to the following systemic treatments: physiological saline solution (PSS); CIS and 5FU. Each group was subdivided into two subgroups: without (NEP) and with (EP) induction of EP. Animals were euthanized at 3, 5 and 7 days post-treatment. Histological, histometric (percentage of bone in the furcation {[}PBF]) and immunohistochemical (for tumour necrosis factor-alpha, interleukin-1 beta and receptor activator of nuclear factor-kappa B ligand) analyses were performed. Data were statistically analysed. Results CIS-NEP and 5FU-NEP showed more inflammation than PSS-NEP at 3, 5 and 7 days. CIS-EP and 5FU-EP showed more inflammation and lower PBF than PSS-EP at all periods of evaluation. 5FU-EP showed lower PBF than CIS-EP at 5 and 7 days. Conclusion 5-FU and CIS exacerbated periodontal inflammation and aggravated the progression of EP in its early stages. (AU)

• Processo FAPESP: 14/11427-8 - Influência de drogas quimioterápicas na evolução da periodontite experimental em ratos
• Beneficiário: Juliano Milanezi de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular