Effect of irradiation with intravascular laser on the hemodynamic variables of hypertensive patients Study protocol for prospective blinded randomized clinical trial

Autor(es)

Jordao Isabella, Adriana Paula ^[1] ; Costa Silva, Jessica Tayane ^[2] ; da Silva, Tamiris ^[3] ; Setubal Destro Rodrigues, Maria Fernanda ^[1] ; Ratto Tempestini Horliana, Anna Carolina ^[1] ; Motta, Lara Jansiski ^[1] ; Bussadori, Sandra Kalil ^[1] ; Pavani, Christiane ^[1] ; Teixeira da Silva, Daniela de Fatima ^[1]

Afiliação do(s) autor(es)

^[1] Nove de Julho Univ UNINOVE, Post Grad Program Biophoton, Sao Paulo - Brazil

^[2] Nove de Julho Univ UNINOVE, Dept Hlth, Nursing, Sao Paulo - Brazil

^[3] Nove de Julho Univ UNINOVE, Post Grad Program Rehabil Sci, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MEDICINE; v. 98, n. 14 APR 2019.
• Citações Web of Science: 0

Resumo

Background: High blood pressure (HBP) is a multifactorial clinical condition, with a high morbidity and mortality rate and low rates of control. Due to its high prevalence, it is necessary to search for methods which aim to improve the quality of life of hypertensive patients. Studies have shown that low level laser therapy (LLLT) is capable of inducing a photobiological response within the cells which modifies the micro and macrovascular response; this accompanies evidence showing the systemic effects of intravascular laser irradiation of blood (ILIB). In the hypothesis that the use of LLLT can influence blood pressure levels, and perhaps facilitate adherence to treatment, this study aims to present a clinical research protocol with the goal of determining the effect of photobiomodulation in relation to changes in the hemodynamic parameters of hypertensive and normotensive patients. Method: Forty-four participants, frequent attendees of an ambulatory university clinic, will be subdivided into 4 groups, and then submitted to protocol sessions of ILIB. The technique is noninvasive and consists of a laser which is attached to a bracelet which has been specifically developed for the light beam to be transcutaneously carried over the radial artery. Before the procedure, at the end of the photobiomodulation cycles, and 1 month after the end of therapy, blood samples will be collected for the evaluation of Creactive protein, interleukin 6, and nitric oxide, to be analyzed by immunoturbidimetric, ELISA, and Griess reactions, respectively. Analysis of results: Results will be analyzed using descriptive and inferential statistics and will be compiled into tables and/or graphs, with the help of SPSS version 24.0 with the adopted significance level for all tests being alpha=0.05. Discussion: The treatment of HBP involves both pharmacological and nonpharmacological therapy. Animal studies with photobiomodulation have previously shown hypotensive effects. Gaps in the literature exist regarding the applicability of this nonpharmacological therapy in humans. This study aims toconsider the possibility of offeringnonpharmacological therapy to hypertensive patients with the goal of increasing adherence to the treatment as well as minimizing morbidity and mortality caused by hypertension. (AU)

• Processo FAPESP: 18/19615-9 - Laser intravascular em pacientes hipertensos: estudo clínico controlado randomizado e cego
• Beneficiário: Jéssica Tayane Costa Silva
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica