Oral Manifestation of Lymphomatoid Granulomatosis

Autor(es)

Costa Pereira, Alessandro Antonio ^[1] ; Ferreira, Christian Barros ^[2] ; Costa Hanemann, Joao Adolfo ^[3] ; Ribeiro Paranaiba, Livia Maris ^[1] ; Iucif Pereira, Patricia Peres ^[4] ; Rodrigues-Fernandes, Carla Isabelly ^[5] ; Sanchez-Romero, Celeste ^[5] ; de Almeida, Oslei Paes ^[5] ; Fonseca, Felipe Paiva ^{[5, 6]}

Afiliação do(s) autor(es)

^[1] Univ Fed Alfenas, Dept Pathol & Parasitol, Inst Biomed Sci, Alfenas - Brazil

^[2] Conego Monte Raso Hosp, Baependi - Brazil

^[3] Univ Fed Alfenas, Dept Clin & Surg, Sch Dent, Alfenas - Brazil

^[4] Univ Jose Rosario Vellano, Sch Dent, Varginha - Brazil

^[5] Univ Estadual Campinas, Dept Oral Diag, Piracicaba Dent Sch, Piracicaba - Brazil

^[6] Univ Fed Minas Gerais, Dept Oral Surg & Pathol, Sch Dent, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Head and Neck Pathology; v. 13, n. 2, p. 270-276, JUN 2019.
• Citações Web of Science: 1

Resumo

Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder driven by Esptein-Barr virus (EBV) that most commonly affects the lungs, although extra pulmonary sites like the central nervous system, skin, liver and kidney can also be involved. It is microscopically characterized by an angiocentric and angiodestructive growth pattern, predominantly composed by small T-cells, although a smaller population of atypical large B-cells is considered the true neoplastic component. Oral cavity involvement of LYG has rarely been described and the diagnosis of this neoplasm is very difficult. The aim of this report is to present a rare case of LYG affecting an 86-year-old female patient that was diagnosed due to an extensive, ulcerated and painful oral lesion affecting the hard palate. Detailed microscopic evaluation together with a large immunohistochemical study were necessary to achieve the correct diagnosis of LYG. (AU)

• Processo FAPESP: 17/14880-3 - Análise clinicopatológica e imunoistoquímica das hiperplasias linfoides foliculares e dos linfomas da cavidade oral
• Beneficiário: Oslei Paes de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular