How many copies of GSTM1 and GSTT1 are associated with head and neck cancer risk?

Autor(es)

Firigato, Isabela ^[1] ; Goncalves, Fernanda de Toledo ^[1] ; De Antonio, Juliana ^[1] ; Curioni, Otavio Alberto ^[2] ; Silva, Mariana Rocha ^[1] ; Figaro Gattas, Gilka Jorge ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo FMUSP, Fac Med, Inst Oscar Freire, Dept Med Legal Etica Med Med Social & Trabalho, LIM 40, 455 Dr Arnaldo Ave, BR-01246903 Sao Paulo, SP - Brazil

^[2] Hosp Heliopolis, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOMARKERS; v. 24, n. 3, p. 262-267, APR 3 2019.
• Citações Web of Science: 0

Resumo

Purpose: GSTM1 and GSTT1 present a polymorphism that can drive complete gene deletions. The current methodology can powerfully determine GSTM1 and GSTT1 copy number variations (CNVs), which may clarify the real contribution of each gene copies to the cellular detoxification process and tumour risk. However, only analysing the presence/absence of these genes yielded controversial results for several disorders, including cancer. Because head and neck cancer (HNC) is becoming a serious global health problem, this study determined the CNVs of GSTM1 and GSTT1 in an HNC case-control population and investigated the possible association between gene copy numbers and tumour risk. Methods: CNV was evaluated by (Ct) 2(-Delta Delta Ct) qPCR methodology in 619 HNC patients and 448 patients with no tumour diagnosis. Results: The genes copy number range was 0-3. The CNV of GSTM1 and GSTT1 frequencies were similar between the cases and control. Thus, none copy of GSTM1 and GSTT1 were associated with HNC risk. Notwithstanding, one copy of both genes had higher frequencies among individuals who carried GSTM1 and GSTT1. Conclusions: One copy number of GSTM1 and GSTT1 presented a higher frequency among carrier genes, but the CNV of GSTM1 and GSTT1 was not associated with HNC risk. (AU)

• Processo FAPESP: 14/16092-4 - Os polimorfismos genéticos podem contribuir na prevenção e tratamento do câncer de cabeça e pescoço?
• Beneficiário: Gilka Jorge Figaro Gattas
• Modalidade de apoio: Auxílio à Pesquisa - Regular