Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria

Autor(es)

Lima, Renata ^[1] ; Del Fiol, Fernando Sa ^[2] ; Balcao, Victor M. ^{[3, 4, 5]}

Afiliação do(s) autor(es)

^[1] Univ Sorocaba, LABiToN Lab Bioact Assessment & Toxicol Nanomat, Sorocaba - Brazil

^[2] Univ Sorocaba, CRIA Antibiot Reference & Informat Ctr, Sorocaba - Brazil

^[3] Univ Aveiro, Dept Biol, Campus Univ Santiago, Aveiro - Portugal

^[4] Univ Aveiro, CESAM, Campus Univ Santiago, Aveiro - Portugal

^[5] Univ Sorocaba, Ibs2 Intelligent Biosensing & Biomol Stabilizat, PhageLab Lab Biofilms & Bacteriophages, Sorocaba - Portugal

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHARMACOLOGY; v. 10, JUN 21 2019.
• Citações Web of Science: 2

Resumo

The increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence of bacteria resistant to the antibiotics currently available, as well as to the selective development of other microorganisms, hence contributing to the widespread dissemination of resistance genes at the environmental level. Due to this, attempts are being made to develop new techniques to combat resistant bacteria, among them the use of strictly lytic bacteriophage particles, CRISPR-Cas, and nanotechnology. The use of these technologies, alone or in combination, is promising for solving a problem that humanity faces today and that could lead to human extinction: the domination of pathogenic bacteria resistant to artificial drugs. This prospective paper discusses the potential of bacteriophage particles, CRISPR-Cas, and nanotechnology for use in combating human (bacterial) infections. (AU)

• Processo FAPESP: 16/12234-4 - TransAppIL - Permeação cutânea de entidades proteicas estabilizadas estruturalmente e funcionalmente, carreadas por líquidos iônicos.
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• Processo FAPESP: 18/05522-9 - PsaPhageKill - isolamento, caracterização e uso de bacteriófagos líticos contra Pseudomonas syringae pv. actinidiae para combater o cancro do kiwi: uma alternativa eficiente e amiga do ambiente
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