Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria

Full text
Lima, Renata [1] ; Del Fiol, Fernando Sa [2] ; Balcao, Victor M. [3, 4, 5]
Total Authors: 3
[1] Univ Sorocaba, LABiToN Lab Bioact Assessment & Toxicol Nanomat, Sorocaba - Brazil
[2] Univ Sorocaba, CRIA Antibiot Reference & Informat Ctr, Sorocaba - Brazil
[3] Univ Aveiro, Dept Biol, Campus Univ Santiago, Aveiro - Portugal
[4] Univ Aveiro, CESAM, Campus Univ Santiago, Aveiro - Portugal
[5] Univ Sorocaba, Ibs2 Intelligent Biosensing & Biomol Stabilizat, PhageLab Lab Biofilms & Bacteriophages, Sorocaba - Portugal
Total Affiliations: 5
Document type: Journal article
Source: FRONTIERS IN PHARMACOLOGY; v. 10, JUN 21 2019.
Web of Science Citations: 2

The increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence of bacteria resistant to the antibiotics currently available, as well as to the selective development of other microorganisms, hence contributing to the widespread dissemination of resistance genes at the environmental level. Due to this, attempts are being made to develop new techniques to combat resistant bacteria, among them the use of strictly lytic bacteriophage particles, CRISPR-Cas, and nanotechnology. The use of these technologies, alone or in combination, is promising for solving a problem that humanity faces today and that could lead to human extinction: the domination of pathogenic bacteria resistant to artificial drugs. This prospective paper discusses the potential of bacteriophage particles, CRISPR-Cas, and nanotechnology for use in combating human (bacterial) infections. (AU)

FAPESP's process: 17/13328-5 - Development and evaluation of biogenic metal nanoparticles (silver, titanium and iron) based on Trichoderma harzianum for agricultural application
Grantee:Renata de Lima
Support type: Regular Research Grants
FAPESP's process: 18/05522-9 - PsaPhageKill - isolation, characterisation and use of lytic bacteriophages against Pseudomonas syringae PV. actinidiae to fight the cancer of kiwifruit: an efficient and ecofriendly alternative
Grantee:Vitor Manuel Cardoso Figueiredo Balcão
Support type: Scholarships abroad - Research
FAPESP's process: 16/08884-3 - PneumoPhageColor - development of a colorimetric biodetection kit for Pseudomonas aeruginosa based on phage particles
Grantee:Vitor Manuel Cardoso Figueiredo Balcão
Support type: Regular Research Grants
FAPESP's process: 16/12234-4 - TransAppIL - Transdermal delivery of structurally and functionally stabilized protein entities applying ionic liquids.
Grantee:Marta Maria Duarte Carvalho Vila
Support type: Regular Research Grants