Multitasking of bacteriocinogenic beneficial microorganisms (lactic acid bacteria and Bacillus spp.) in food safety and health promoting applications

• Grant number: 23/05394-9
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2024
• End date: January 31, 2026
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Svetoslav Dimitrov Todorov
• Grantee: Svetoslav Dimitrov Todorov
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Ana Lúcia Barretto Penna ; Bernadette Dora Gombossy de Melo Franco
• Associated research grant(s): 24/01721-8 - Health beneficial properties of bacteriocins produced by lactic acid bacteria isolated from indigenous fermented products, AP.R

Abstract

Many studies have evaluated a wide range of bacteriocins produced by probiotic lactic acid bacteria (LAB) and strains of Bacillus spp. in food safety, but their use as alternatives for biopreservation and as new antimicrobial drugs for medical purposes has not been sufficiently explored yet. The use of bacteriocins to fight vancomycin resistant enterococci, methicillin resistant staphylococci, viruses, Mycobacterium and fungus is very promising. Given the potential for use in the medical field, an in-depth characterization of bacteriocins is essential for their successful application. This project aims at the selection of probiotic strains from different traditional and/or fermented food products, and those presenting antimicrobial properties will be explored for additional beneficial properties, to be used in food safety and clinical practices related to the combat against multidrug resistance pathogens, reduction of toxins, production of antioxidant, GABA and other bioactive metabolites, in oral health, in the accompanying therapies, including cancer. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, DEBORA PRECELIANO; TODOROV, SVETOSLAV DIMITROV; FABI, JOAO PAULO. Exploring the Prebiotic Potentials of Hydrolyzed Pectins: Mechanisms of Action and Gut Microbiota Modulation. NUTRIENTS, v. 16, n. 21, p. 23-pg., 2024-11-01. (13/07914-8, 22/12834-2, 23/05394-9)

BUCHELI, JORGE ENRIQUE VAZQUEZ; LEE, YURI; KIM, BOBAE; AZEVEDO, NUNO F.; AZEVEDO, ANDREIA S.; TODOROV, SVETOSLAV DIMITROV; JI, YOSEP; KANG, HYEJI; HOLZAPFEL, WILHELM H.. Use of FISH-FLOW as a Method for the Identification and Quantification of Bacterial Populations. MOLECULAR NUTRITION & FOOD RESEARCH, v. N/A, p. 12-pg., 2024-10-03. (23/05394-9)

LIMA, JOAO MARCOS SCAFURO; CARNEIRO, KAYQUE ORDONHO; PINTO, UELINTON MANOEL; TODOROV, SVETOSLAV DIMITROV. Bacteriocinogenic anti-listerial properties and safety assessment of Enterococcus faecium and Lactococcus garvieae strains isolated from Brazilian artisanal cheesemaking environment. Journal of Applied Microbiology, v. 135, n. 7, p. 16-pg., 2024-07-27. (13/07914-8, 23/14944-2, 23/05394-9)

TODOROV, SVETOSLAV D.; TAGG, JOHN; ALGBURI, AMMAR; TIWARI, SANTOSH KUMAR; POPOV, IGOR; WEEKS, RICHARD; MITROKHIN, OLEG V.; KUDRYASHOV, ILYA A.; KRASKEVICH, DENIS A.; CHIKINDAS, MICHAEL L.. The Hygienic Significance of Microbiota and Probiotics for Human Wellbeing. PROBIOTICS AND ANTIMICROBIAL PROTEINS, v. N/A, p. 31-pg., 2024-12-17. (23/05394-9)

CARNEIRO, KAYQUE ORDONHO; CAMPOS, GABRIELA ZAMPIERI; LIMA, JOAO MARCOS SCAFURO; ROCHA, RAMON DA SILVA; VAZ-VELHO, MANUELA; TODOROV, SVETOSLAV DIMITROV. The Role of Lactic Acid Bacteria in Meat Products, Not Just as Starter Cultures. FOODS, v. 13, n. 19, p. 22-pg., 2024-10-01. (24/01721-8, 22/14824-4, 23/14944-2, 23/05394-9)

MERZOUG, MOHAMED; ZATER, ZOHRA YASMINE; MOSBAHI, KHEDIDJA; WALKER, DANIEL; TODOROV, SVETOSLAV DIMITROV; SAIDI, DJAMAL. Synthetic Biology-Based Heterologous Expression and Purification of Enterocin A: Advancing Antimicrobial Peptide Applications. MOLECULAR NUTRITION & FOOD RESEARCH, v. N/A, p. 12-pg., 2025-09-12. (23/05394-9)

MANTOVAM, VINICIUS B.; DOS SANTOS, DAVID F.; GIOLA, LUIS C.; LANDGRAF, MARIZA; PINTO, UELINTON M.; TODOROV, SVETOSLAV D.. Listeria monocytogenes, Salmonella spp., and Staphylococcus aureus: Threats to the Food Industry and Public Health. FOODBORNE PATHOGENS AND DISEASE, v. N/A, p. 16-pg., 2025-01-06. (24/01721-8, 23/05394-9, 23/02522-6, 13/07914-8)

LIPILKINA, TATIANA ALEXANDROVNA; XU, CRISTHIAN; BARBOSA, MATHEUS DE SOUZA; KHRAMOVA, VALENTINA NIKOLAEVNA; SHEBEKO, SERGEI K.; ERMAKOV, ALEXEY M.; IVANOVA, ISKRA VITANOVA; TODOROV, SVETOSLAV DIMITROV. Beneficial and Safety Properties of a Bacteriocinogenic and Putative Probiotic Latilactobacillus sakei subsp. sakei 2a Strain. FOODS, v. 13, n. 23, p. 21-pg., 2024-12-01. (23/05394-9, 24/01721-8)

MORETTI, MARCIA MARIA DE SOUZA; BORGONOVI, TAIS FERNANDA; TODOROV, SVETOSLAV DIMITROV; PENNA, ANA LUCIA BARRETTO. Banana Pseudostem By-Product: A Sustainable Source of Prebiotics and Protection for Probiotic Lactic Acid Bacteria Under Gastrointestinal Conditions. FERMENTATION-BASEL, v. 11, n. 8, p. 17-pg., 2025-08-20. (21/07441-9, 23/05394-9)

TODOROV, SVETOSLAV DIMITROV; ALVES, MARCOS VINICIO; BUENO, GISANA CRISTINA ALVES; ALVES, VIRGINIA FARIAS; IVANOVA, ISKRA VITANOVA. Bee-Associated Beneficial Microbes-Importance for Bees and for Humans. INSECTS, v. 15, n. 6, p. 20-pg., 2024-06-01. (23/05394-9)