Effects of sleep restriction during pregnancy on lipids and glucose homeostasis of female offspring submitted to ovariectomy

Autor(es)

Argeri, Rogerio ^[1] ; Carvalho, Diego Soares ^{[1, 2]} ; Palma, Beatriz Duarte ^[3] ; Hirata, Aparecida Emiko ^[1] ; Gomes, Guiomar Nascimento ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Physiol, UNIFESP, Sao Paulo, SP - Brazil

^[2] Fed Inst Educ Sci & Technol, Rondonia - Brazil

^[3] Ctr Univ Sao Camilo, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE; v. 10, n. 3, p. 334-337, JUN 2019.
• Citações Web of Science: 0

Resumo

Sleep shortening during pregnancy may alter the mother's environment, affecting the offspring. Thus, the present study evaluated the metabolic profile of female offspring from sleep-restricted rats during the last week of pregnancy. Pregnant Wistar rats were distributed into two groups: control (C) and sleep restriction (SR). The SR was performed 20 h/day, from 14th to 20th day of pregnancy. At 2 months, half of the offspring were subjected to ovariectomy (OVX); the others, to sham surgery. Studied groups were Csham, Covx, SRsham and SRovx. Cholesterol (HDL, LDL and C-total), triglycerides (TG) and glucose and insulin tolerance tests (GTT-ITT) were evaluated at 8 months. RSsham presented higher values of TG, while SRovx presented higher TG, LDL and C-total. Basal glucose concentration was increased in SRsham and SRovx. These data suggest that SR during pregnancy may be a risk factor for the development of diseases in adult female offspring. (AU)

• Processo FAPESP: 13/23622-7 - Estudo das alterações cardiovasculares e renais da prole de ratas submetidas à restrição de sono durante a prenhez
• Beneficiário: Guiomar Nascimento Gomes
• Modalidade de apoio: Auxílio à Pesquisa - Regular