Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Clinical impact of PET/MR in treated colorectal cancer patients

Texto completo
Autor(es):
Mostrar menos -
Amorim, Barbara J. [1, 2, 3] ; Hong, Theodore S. [4] ; Blaszkowsky, Lawrence S. [5] ; Ferrone, Cristina R. [6] ; Berger, David L. [6] ; Bordeianou, Liliana G. [6] ; Ricciardi, Rocco [6] ; Clark, Jeffrey W. [5] ; Ryan, David P. [5] ; Wo, Jennifer Y. [4] ; Qadan, Motaz [6] ; Vangel, Mark [1, 2, 7] ; Umutlu, Lale [8] ; Groshar, David [9, 10] ; Canamaques, Lina G. [11] ; Gervais, Debra A. [1] ; Mahmood, Umar [1, 2] ; Rosen, Bruce R. [2] ; Catalano, Onofrio A. [1, 2, 12]
Número total de Autores: 19
Afiliação do(s) autor(es):
Mostrar menos -
[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, 55 Fruit St, White 270, Boston, MA 02114 - USA
[2] Harvard Med Sch, Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Boston, MA 02115 - USA
[3] State Univ Campinas UNICAMP, Div Nucl Med, Campinas, SP - Brazil
[4] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02115 - USA
[5] Harvard Med Sch, Massachusetts Gen Hosp, Dept Hematol Oncol, Boston, MA 02115 - USA
[6] Harvard Med Sch, Massachusetts Gen Hosp, Dept Surg, Boston, MA 02115 - USA
[7] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Biostat, Boston, MA 02115 - USA
[8] Univ Hosp Essen, Dept Diagnost & Intervent Radiol & Neuroradiol, Essen - Germany
[9] Tel Aviv Univ, Sackler Sch Med, Tel Aviv - Israel
[10] Assuta Med Ctr, Dept Nucl Med, Tel Aviv - Israel
[11] Hosp Univ Madrid Sanchinarro, Madrid - Spain
[12] Univ Naples Parthenope, Dept Radiol, Naples - Italy
Número total de Afiliações: 12
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; v. 46, n. 11, p. 2260-2269, OCT 2019.
Citações Web of Science: 0
Resumo

Purpose The primary aim of the present study was to evaluate if PET/MR induced management changes versus standard of care imaging (SCI) in treated colorectal cancer patients. The secondary aim was to assess the staging performance of PET/MR and of SCI versus the final oncologic stage. Methods Treated CRC patients who underwent PET/MR with F-18-FDG and SCI between January 2016 and October 2018 were enrolled in this retrospective study. Their medical records were evaluated to ascertain if PET/MR had impacted on their clinical management versus SCI. The final oncologic stage, as reported in the electronic medical record, was considered the true stage of disease. Results A total of 39 patients who underwent 42 PET/MR studies were included, mean age 56.7 years (range 39-75 years), 26 males, and 13 females. PET/MR changed clinical management 15/42 times (35.7%, standard error +/- 7.4%); these 15 changes in management were due to upstaging in 9/42 (21.5%) and downstaging in 6/42 (14.2%). The differences in management prompted by SCI versus PET/MR were statistically significant, and PET/MR outperformed SCI (P value < 0.001; odds ratio = 2.8). In relation to the secondary outcome, PET/MR outperformed the SCI in accuracy of oncologic staging (P value = 0.016; odds ratio = 4.6). Conclusions PET/MR is a promising imaging tool in the evaluation of treated CRC and might change the management in these patients. However, multicenter prospective studies with larger patient samples are required in order to confirm these preliminary results. (AU)

Processo FAPESP: 17/27205-2 - Impacto clinico do PET/RM com FDG-18F em pacientes com câncer coloretal tratado
Beneficiário:Bárbara Juarez Amorim
Modalidade de apoio: Bolsas no Exterior - Pesquisa