The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon

Autor(es):Mostrar menos -

Pires, Eder Soares ^{[1, 2]} ; Pires Hardoim, Cristiane Cassiolato ^[3] ; Miranda, Karla Rodrigues ^[1] ; Secco, Danielle Angst ^[1] ; Lobo, Leandro Araujo ^[1] ; de Carvalho, Denise Pires ^[4] ; Han, Jun ^[5] ; Borchers, Christoph H. ^{[5, 6, 7, 8]} ; Ferreira, Rosana B. R. ^[1] ; Salles, Joana Falcao ^[9] ; Cavalcanti Pilotto Domingues, Regina Maria ^[1] ; Martha Antunes, Luis Caetano ^{[10, 11]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Rio De Janeiro - Brazil

^[2] Inst Tecnol Vale Dev Sustentavel, Belem, Para - Brazil

^[3] Univ Estadual Paulista, Inst Biociencias, Sao Vicente - Brazil

^[4] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Rio de Janeiro - Brazil

^[5] Univ Victoria, Genome British Columbia Prote Ctr, Victoria, BC - Canada

^[6] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC - Canada

^[7] McGill Univ, Jewish Gen Hosp, Segal Canc Prote Ctr, Lady Davis Inst, Montreal, PQ - Canada

^[8] McGill Univ, Gerald Bronfman Dept Oncol, Jewish Gen Hosp, Montreal, PQ - Canada

^[9] Univ Groningen, Groningen Inst Evolutionary Life Sci, Microbial Ecol Cluster, Groningen - Netherlands

^[10] Fundacao Oswaldo Cruz, Escola Nacl Saude Publ Sergio Arouca, Rio De Janeiro - Brazil

^[11] Fundacao Oswaldo Cruz, Inst Nacl Ciencia & Tecnol Inovacao Doencas Popul, Ctr Dev Tecnol Saude, Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN MICROBIOLOGY; v. 10, SEP 4 2019.
• Citações Web of Science: 0

Resumo

During the last decades it has become increasingly clear that the microbes that live on and in humans are critical for health. The communities they form, termed microbiomes, are involved in fundamental processes such as the maturation and constant regulation of the immune system. Additionally, they constitute a strong defense barrier to invading pathogens, and are also intricately linked to nutrition. The parameters that affect the establishment and maintenance of these microbial communities are diverse, and include the genetic background, mode of birth, nutrition, hygiene, and host lifestyle in general. Here, we describe the characterization of the gut microbiome of individuals living in the Amazon, and the comparison of these microbial communities to those found in individuals from an urban, industrialized setting. Our results showed striking differences in microbial communities from these two types of populations. Additionally, we used high-throughput metabolomics to study the chemical ecology of the gut environment and found significant metabolic changes between the two populations. Although we cannot point out a single cause for the microbial and metabolic changes observed between Amazonian and urban individuals, they are likely to include dietary differences as well as diverse patterns of environmental exposure. To our knowledge, this is the first description of gut microbial and metabolic profiles in Amazonian populations, and it provides a starting point for thorough characterizations of the impact of individual environmental conditions on the human microbiome and metabolome. (AU)

• Processo FAPESP: 17/10157-5 - Holobioma das esponjas marinhas, efeitos das mudanças climáticas e potenciais biotecnológicos: uma abordagem holística e multidisciplinar
• Beneficiário: Cristiane Cassiolato Pires Hardoim
• Modalidade de apoio: Bolsas no Brasil - Programa de Pesquisa sobre Mudanças Climáticas Globais - Jovens Pesquisadores