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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

NFAT1 Regulates Ly6C(hi) Monocyte Recruitment to the CNS and Plays an Essential Role in Resistance to Toxoplasma gondii Infection

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Autor(es):
Benevides, Luciana [1, 2] ; Saltarelli, Veronica M. [1] ; Pioto, Franciele [1, 2] ; Sacramento, Lais A. [1] ; Dias, Murilo S. [1] ; Rodriguez, Gretel R. [1] ; Viola, Joao P. B. [3] ; Carregaro, Vanessa [1] ; Silva, Joao S. [1, 2]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Biochem & Immunol, Ribeirao Preto Med Sch, Ribeirao Preto - Brazil
[2] Fiocruz Bi Inst Translat Med Plataform, Ribeirao Preto - Brazil
[3] Brazilian Natl Canc Inst INCA, Program Immunol & Tumor Biol, Rio De Janeiro - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN IMMUNOLOGY; v. 10, SEP 6 2019.
Citações Web of Science: 0
Resumo

Monocytes play key roles in the maintenance of homeostasis and in the control of the infection. Monocytes are recruited from the bone marrow to inflammatory sites and are essential for antimicrobial activity to limit tissue damage and promote adaptive T cell responses. Here, we investigated the role of Nuclear Factor of Activated T cells 1 (NFAT1) in the regulation of Ly6C(hi) inflammatory monocyte recruitment to the CNS upon T. gondii infection. We show that NFAT-1-deficient monocytes are unable to migrate to the CNS of T. gondii-infected mice. Moreover, NFAT1(-/-) mice are highly susceptible to chronic T. gondii infection due to a failure to control parasite replication in the CNS. The inhibition of Ly6C(hi) inflammatory monocyte recruitment to the CNS severely blocked CXCL10 production and consequently the migration of IFN-gamma-producing CD4(+) T cells. Moreover, the transfer of Ly6C(hi) monocytes to infected NFAT1(-/-) mice favored CD4(+) T cell migration to the CNS and resulted in the inhibition of parasite replication and host defense. Together, these results demonstrated for the first time the contribution of NFAT1 to the regulation of Ly6C(hi) monocyte recruitment to the CNS and to resistance during chronic T. gondii infection. (AU)

Processo FAPESP: 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias
Beneficiário:Fernando de Queiroz Cunha
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs