Long Term Effectiveness of Photodynamic Therapy for CIN Treatment

Autor(es)

Inada, Natalia Mayumi ^[1] ; Buzza, Hilde Harb ^[1] ; Martins Leite, Marieli Fernanda ^[2] ; Kurachi, Cristina ^[1] ; Trujillo, Jose Roberto ^[3] ; de Castro, Cynthia Aparecida ^{[4, 1]} ; Carbinatto, Fernanda Mansano ^[1] ; Lombardi, Welington ^[2] ; Bagnato, Vanderlei Salvador ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Carlos, SP - Brazil

^[2] Centro Univ Araraquara, Woman Hlth Ambulatory, BR-14801308 Araraquara, SP - Brazil

^[3] TruCyton LLC, Rockville, MD 20851 - USA

^[4] Univ Fed Sao Carlos, Dept Morphol & Pathol, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHARMACEUTICALS; v. 12, n. 3 SEP 2019.
• Citações Web of Science: 0

Resumo

(1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018-2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions). The present study reports the long-term effectiveness of topical photodynamic therapy (PDT) for CIN grades 1 and 2/3 with up to two years of follow up. (2) Methods: A total of 56 patients with CIN 1, ten with CIN 2, and 14 patients for the placebo group were enrolled in this study. (3) Results: 75% (n = 42) of CIN 1 patients presented a complete response to PDT and only 23.2% (n = 13) of recurrence, progression, and/or lesions remaining two years after PDT. For CIN 2/3 patients, 90% were observed to be cured after one and two years of follow up. (4) Conclusions: PDT presented best results two years after a non-invasive, fast, and low-cost procedure and in comparison with the placebo group, preventing the progression of cervical intraepithelial neoplasia and preserving the cervix. (AU)

• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/50857-8 - INCT 2014 - de Óptica Básica e Aplicada às Ciências da Vida
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Temático