Gold Nanoparticle Paper-Based Dual-Detection Device for Forensics Applications

Autor(es)

Ameku, Wilson A. ^[1] ; de Araujo, William R. ^[2] ; Rangel, Clara J. ^[1] ; Ando, Romulo A. ^[1] ; Paixao, Thiago R. L. C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Chem, BR-05508000 Sao Paulo, SP - Brazil

^[2] State Univ Campinas UNICANIP, Dept Analyt Chem, Inst Chem, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACS APPLIED NANO MATERIALS; v. 2, n. 9, p. 5460-5468, SEP 2019.
• Citações Web of Science: 0

Resumo

Drug trafficking is a major worldwide problem. In this context, cocaine is one of the most commonly used drugs of abuse. In addition, street cocaine is commonly seized adulterated with pharmaceutical compounds, and the composition of the mixture provides a chemical fingerprint that can assist the police in tracking the distribution route of the drug; hence, the development of facile, cost-effective methods for determining the composition of street cocaine is an important objective. Herein we report a simple strategy for the fabrication of paper-based analytical devices (PADs) for the dual electrochemical and surface-enhanced Raman scattering (SERS) determination of cocaine samples. Accordingly, a 2-mu m-thick Au film was prepared by depositing gold nanoparticles (AuNPs) on office paper with wax-barrier templates to create nanostructured gold tracks that are mainly formed by Au(111) fcc planes as electrodes and SERS transducers. These devices were characterized by scanning electron microscopy, X-ray diffractometry, electrochemical impedance spectroscopy, and energy-dispersive X-ray spectroscopy. The optimized device is simple and inexpensive to prepare and exhibited a Raman-scattering enhancement factor of 3 X 10(6), a 15-fold superior electroactive area, and a 2.6-fold decrease in charge-transfer resistance when compared with a conventional Au electrode. In addition, these PADs were successfully used in a forensics scenario to screen and analyze a seized street cocaine sample, determine its chemical profile, and to identify simultaneously caffeine, paracetamol, and levamisole adulterants. (AU)

• Processo FAPESP: 16/21070-5 - Espectroscopia vibracional com resolução espacial
• Beneficiário: Mauro Carlos Costa Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/10522-5 - Desenvolvimento de métodos alternativos para fabricação de sensores eletroquímicos em papel
• Beneficiário: Thiago Regis Longo Cesar da Paixão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/08782-1 - Sensores químicos miniaturizados e integrados: novas plataformas de fabricação para aplicações biológicas, clínicas e ambientais
• Beneficiário: Mauro Bertotti
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/16477-9 - Fabricação de dispositivos analíticos portáteis baseados em plataformas de papel com sistema de detecção eletroquímica e colorimétrica visando aplicações forenses, clínicas e ambientais
• Beneficiário: William Reis de Araujo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado