ZnO nanorods-gold nanoparticle-based biosensor for detecting hepatitis C

Autor(es)

Biasotto, Glenda ^[1] ; Costa, Joao Paulo C. ^[1] ; Costa, I, Paulo ; Zaghete, Maria A. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Chem, LIEC, BR-14800060 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING; v. 125, n. 12 DEC 2019.
• Citações Web of Science: 0

Resumo

ZnO nanorods comprised of biosensors with Au nanoparticles are described in this study for detecting Hepatitis C virus (HCV). The biosensor device was constructed on a glass substrate with silver and gold electrodes. The ZnO nanorods were grown by microwave hydrothermal synthesis, and the Au nanoparticles were deposited by the sputtering method. The Au nanoparticles were deposited because of the right efficient of anti-HCV antibodies with cystamine and glutaraldehyde. The ZnO nanorods were evaluated using SEM images. The electrochemical biosensor shows a sensitive response to HCV with a detection limit of 0.25 mu g/mu L. The proposed sensor characteristics of high specificity, good reproducibility and remarkable stability will provide a sensitive, selective, and convenient approach for the detection of HCV. (AU)

• Processo FAPESP: 11/19561-7 - Desenvolvimento de Nanoestruturas e Filmes de ZnO para Aplicação em Sensores e Nanogeradores.
• Beneficiário: Glenda Biasotto
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Elson Longo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs