HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome

Autor(es)

Rodrigues, Lucas S. ^[1] ; da Silva Nali, Luiz H. ^{[1, 2]} ; Leal, Cibele O. D. ^[1] ; Sabino, Ester C. ^{[1, 3]} ; Lacerda, Eliana M. ^[4] ; Kingdon, Caroline C. ^[4] ; Nacul, Luis ^[4] ; Romano, Camila M. ^{[5, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Lab Virol, Rua Dr Eneas Carvalho Aguiar 470, BR-05403000 Sao Paulo, SP - Brazil

^[2] Univ Santo Amaro, Posgrad Ciencias Saude, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Dept Molestias Infecciosas & Parasit, Sao Paulo - Brazil

^[4] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Clin Res, London - England

^[5] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP LIM52, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AUTOIMMUNITY HIGHLIGHTS; v. 10, n. 1 DEC 2019.
• Citações Web of Science: 1

Resumo

Background Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases. Methods Here the expression of Endogenous retroviruses K and W (HERV-K and HERV-W) was determined in blood from moderately and severely affected ME/CFS patients through real time PCR. Results HERV-K was overexpressed only in moderately affected individuals but HERV-W showed no difference. Conclusions This is the first report about HERV-K differential expression in moderate ME/CFS. Although the relationship between HERVs and ME/CFS has yet to be proven, the observation of this phenomenon deserves further attention. (AU)

• Processo FAPESP: 15/05958-3 - O papel da atividade dos Retrovírus Endógenos Humanos da família W (HERV-W) na patogenia da Esclerose Multipla investigado por meio da análise do transcriptoma de pacientes acometidos
• Beneficiário: Camila Malta Romano
• Modalidade de apoio: Auxílio à Pesquisa - Regular