Optimized one-pot synthesis of monoarylidene and unsymmetrical diarylidene cycloalkanones

Autor(es)

Din, Zia Ud ^[1] ; Rodrigues-Filho, Edson ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, LaBioMMi, CP 676, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARABIAN JOURNAL OF CHEMISTRY; v. 12, n. 8, p. 4756-4763, DEC 2019.
• Citações Web of Science: 1

Resumo

Ionic liquid dimethylammonium dimethylcarbamate (DIMCARB) catalyzed reaction for the synthesis of monoarylidene and unsymmetrical diarylidene cycloalkanones has been developed. Catalytic amount of DIMCARB was used in green solvent (water and ethanol) for different reaction of cyclic and acyclic ketones with different electron donating and withdrawing substituted aldehydes. Yields were recorded from low to excellent. This synthetic methodology provides mild, efficient, and environmentally friendly access to unsymmetrical curcuminoid analogs, avoiding the use of excess catalysts, chlorinated organic solvent, and high temperature reaction. It is green and environmentally sound alternative to the existing protocols for the synthesis of pharmaceutically important unsymmetrical natural product analogs. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. (AU)

• Processo FAPESP: 10/11384-6 - Biotransformação de produtos naturais e sintéticos utilizando micro-organismos endofíticos, uma abordagem quimio-ecológica para a produção de substâncias bioativas
• Beneficiário: Edson Rodrigues Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular