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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Optimized one-pot synthesis of monoarylidene and unsymmetrical diarylidene cycloalkanones

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Author(s):
Din, Zia Ud [1] ; Rodrigues-Filho, Edson [1]
Total Authors: 2
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, LaBioMMi, CP 676, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ARABIAN JOURNAL OF CHEMISTRY; v. 12, n. 8, p. 4756-4763, DEC 2019.
Web of Science Citations: 1
Abstract

Ionic liquid dimethylammonium dimethylcarbamate (DIMCARB) catalyzed reaction for the synthesis of monoarylidene and unsymmetrical diarylidene cycloalkanones has been developed. Catalytic amount of DIMCARB was used in green solvent (water and ethanol) for different reaction of cyclic and acyclic ketones with different electron donating and withdrawing substituted aldehydes. Yields were recorded from low to excellent. This synthetic methodology provides mild, efficient, and environmentally friendly access to unsymmetrical curcuminoid analogs, avoiding the use of excess catalysts, chlorinated organic solvent, and high temperature reaction. It is green and environmentally sound alternative to the existing protocols for the synthesis of pharmaceutically important unsymmetrical natural product analogs. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. (AU)

FAPESP's process: 10/11384-6 - Biotransformation of natural and synthetic products using endophytic microorganisms, a chemical-ecologycal approach for the production of bioactive substances
Grantee:Edson Rodrigues Filho
Support Opportunities: Regular Research Grants