Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass

Autor(es)

Tramontina, Robson ^{[1, 2]} ; Galman, James L. ^[1] ; Parmeggiani, Fabio ^[1] ; Derrington, Sasha R. ^[1] ; Bugg, Timothy D. H. ^[3] ; Turner, Nicholas J. ^[1] ; Squina, Fabio M. ^[4] ; Dixon, Neil ^[1]

Afiliação do(s) autor(es)

^[1] Univ Manchester, Sch Chem, MIB, 131 Princess St, Manchester M1 7DN, Lancs - England

^[2] Univ Estadual Campinas, Postgrad Program Biosci & Technol Bioact Prod BTP, Inst Biol, UNICAMP, 500 Albert Einstein Av, BR-13083852 Campinas, SP - Brazil

^[3] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands - England

^[4] Univ Sorocaba, Program Technol & Environm Proc, Raposo Tavares Rd, Km 92-5 Vila Artura, BR-18023000 Sorocaba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GREEN CHEMISTRY; v. 22, n. 1, p. 144-152, JAN 7 2020.
• Citações Web of Science: 9

Resumo

Sustainable production of fine chemicals and biofuels from renewable biomass offers a potential alternative to the continued use of finite geological oil reserves. However, in order to compete with current petrochemical refinery processes, alternative biorefinery processes must overcome significant costs and productivity barriers. Herein, we demonstrate the biocatalytic production of the versatile chemical building block, coniferol, for the first time, directly from lignocellulosic biomass. Following the biocatalytic treatment of lignocellulose to release and convert ferulic acid with feruloyl esterase (XynZ), carboxylic acid reductase (CAR) and aldo-keto reductase (AKR), this whole cell catalytic cascade not only achieved equivalent release of ferulic acid from lignocellulose compared to alkaline hydrolysis, but also displayed efficient conversion of ferulic acid to coniferol. This system represents a consolidated biodegradation-biotransformation strategy for the production of high value fine chemicals from waste plant biomass, offering the potential to minimize environmental waste and add value to agro-industrial residues. (AU)

• Processo FAPESP: 15/50590-4 - Valorização da lignina em plantas de etanol celulósico: a conversão biocatalítica via ácido ferúlico a produtos químicos de alto valor
• Beneficiário: Fábio Márcio Squina
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOEN - Temático
• Processo FAPESP: 17/23754-1 - Desenvolvimento de uma rota sintética para produção de álcool coniferílico a partir de ácido ferúlico usando uma aldoketo redutase do cupim inferior Coptotermes gestroi
• Beneficiário: Robson Tramontina
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado