Bayesian diagnostic analysis for quantitative trait loci mapping

Autor(es)

Zuanetti, Daiane A. ^[1] ; Pavan Soler, Julia M. ^[2] ; Krieger, Jose E. ^[3] ; Milan, Luis A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Estat, Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Inst Matemat & Estat, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Inst Coracao, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: STATISTICAL METHODS IN MEDICAL RESEARCH; v. 29, n. 8 NOV 2019.
• Citações Web of Science: 0

Resumo

QTL mapping is an important tool for identifying regions in chromosomes which are relevant to explain a response of interest. It is a special case of the regression model where an unknown number of missing (non-observable) covariates is involved leading to a complex variable selection procedure. Although several methods have been proposed to identify QTLs and to estimate parameters in the associated model, minimum attention has been devoted to the estimated model adequacy. In this paper, we present an overview of a few methods for residual and diagnostic analysis in the context of Bayesian regression modeling and adapt them to work with QTL mapping. The motivation of this study is to identify QTLs associated with the blood pressure of F2 rats and check the fitted model adequacy. (AU)

• Processo FAPESP: 18/13964-1 - Abordagem Bayesiana para modelos de mapeamento de QTLs, um caso especial de modelos de mistura e regressão
• Beneficiário: Daiane Aparecida Zuanetti
• Modalidade de apoio: Auxílio à Pesquisa - Regular