Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C

Autor(es)

Medolago, Natalia Bronzatto ^[1] ; Ferrasi, Adriana Camargo ^[1] ; da Rocha, Oswaldo Melo ^[1] ; de Moura Campos Pardini, Maria Ines ^[1] ; Tommasini Grotto, Rejane Maria ^[2] ; Galvani, Aline Faria ^[1] ; Silva, Giovanni Faria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista, Fac Ciencias Agron, Dept Bioproc & Biotecnol, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Revista da Sociedade Brasileira de Medicina Tropical; v. 53, 2020.
• Citações Web of Science: 0

Resumo

Abstract INTRODUCTION: Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C. METHODS: Patients (159) with chronic hepatitis C of both genders were analyzed. RESULTS: Women showed association between HPA-3 polymorphisms and RM. CONCLUSIONS: An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed. (AU)

• Processo FAPESP: 11/22049-6 - Análise de associações de polimorfismos HLA, HPA, indicadores de autoimunidade e manifestações reumatológicas na hepatite C
• Beneficiário: Giovanni Faria Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular