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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C

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Author(s):
Medolago, Natalia Bronzatto [1] ; Ferrasi, Adriana Camargo [1] ; da Rocha, Oswaldo Melo [1] ; de Moura Campos Pardini, Maria Ines [1] ; Tommasini Grotto, Rejane Maria [2] ; Galvani, Aline Faria [1] ; Silva, Giovanni Faria [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP - Brazil
[2] Univ Estadual Paulista, Fac Ciencias Agron, Dept Bioproc & Biotecnol, Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Revista da Sociedade Brasileira de Medicina Tropical; v. 53, 2020.
Web of Science Citations: 0
Abstract

Abstract INTRODUCTION: Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C. METHODS: Patients (159) with chronic hepatitis C of both genders were analyzed. RESULTS: Women showed association between HPA-3 polymorphisms and RM. CONCLUSIONS: An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed. (AU)

FAPESP's process: 11/22049-6 - Analysis of associations of HLA and HPA polymorphisms, indicators of autoimmunity and rheumatic manifestations in hepatitis C
Grantee:Giovanni Faria Silva
Support Opportunities: Regular Research Grants