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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Nontuberculous mycobacterial infections in a Brazilian pediatric population: a seven-year survey

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Autor(es):
Mauch, Renan M. [1] ; Mansinho, Andrea A. S. [2] ; Rocha, Priscilla M. O. [2] ; Zaccariotto, Tania R. [3] ; Levy, Carlos E. [3, 4] ; Nolasco da Silva, Marcos T. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Med Sci, Ctr Invest Pediat, Rua Tessalia Vieira de Camargo 126, BR-13083887 Campinas - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Dept Pediat, Campinas - Brazil
[3] Univ Estadual Campinas, Teaching Hosp, Div Clin Pathol, Microbiol Lab, Campinas - Brazil
[4] Univ Estadual Campinas, Sch Med Sci, Dept Clin Pathol, Campinas - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: PATHOGENS AND GLOBAL HEALTH; v. 114, n. 2 FEB 2020.
Citações Web of Science: 0
Resumo

The aim of this study was to describe the frequency of nontuberculous mycobacteria (NTM) isolation and their related outcomes among pediatric patients of a Brazilian university hospital from 2012 to 2019. NTM were identified in different clinical samples by microbiological culture and molecular-based methods. NTM were isolated from 14 patients, out of whom four (27%) were infected and were treated accordingly. Two were infected with Mycobacterium avium complex (MAC), two with M. abscessus complex (MABSC) and one with M. intracellulare. Two patients had cystic fibrosis-related lung disease and improved after successful NTM eradication. One patient was HIV-positive and died. One patient had severe combined immunodeficiency (SCID)-related pneumonia and is currently being followed-up. We conclude that NTM frequency in our center was low among pediatric patients. Whether this is inherent to Brazilian patients, due to the broad coverage of the Bacille Calmette-Guerin (BCG) vaccine in Brazil, or a result of underdiagnosis remains to be elucidated. (AU)

Processo FAPESP: 18/10614-0 - Resposta imune inata e adaptativa na persistência da infecção pulmonar por Pseudomonas aeruginosa produtora de biofilme na fibrose cística
Beneficiário:Renan Marrichi Mauch
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado