Nanostructured titanium alloy surfaces for enhanced osteoblast response: A combination of morphology and chemistry

Autor(es)

Rangel, Andre L. R. ^[1] ; Falentin-Daudre, Celine ^[2] ; Alves da Silva Pimentel, Bruna Natalia ^[3] ; Vergani, Carlos Eduardo ^[3] ; Migonney, Veronique ^[2] ; Alves Claro, Ana P. R. ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Sao Paulo State Univ, Sch Engn Mat & Technol Dept, Guaratingueta Campus, Sao Paulo, SP - Brazil

^[2] Univ Paris 13, CSPBAT LBPS, Paris - France

^[3] UNESP Sao Paulo State Univ, Dent Sch, Dent & Prosthodont Dept, Araraquara Campus, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SURFACE & COATINGS TECHNOLOGY; v. 383, FEB 15 2020.
• Citações Web of Science: 0

Resumo

This study is part of a new trend in the metallic biomaterials field that searches to use the titanium beta alloys with recognized bulk and surface properties for better biological response. Ti15Mo alloy (wt%) had it surface modified by TiO2 nanotubes growth using the anodic oxidation method and grafted with poly(sodium styrene sulfonate) (PNaSS). The motivation behind the combination of these techniques was to promote a surface, which enables better osteointegration associated with antimicrobial behavior. Surfaces were characterized and subjected to cell culture assays and bacterial colonization to evaluate their in vitro response. The results showed that the surfaces were completely covered with TiO2 nanotubes, which was successfully grafted with PNaSS. Compared with untreated Ti 15Mo surfaces, PNaSS grafted nanotubes surfaces showed better osteoblast cell response in terms of cell attachment and mineralization and weaker bacterial adhesion and colonization. The results suggest that the final product of the combine treatment - nanotube plus PNaSS grafting - represents a promising option to improve commercial metallic implants. (AU)

• Processo FAPESP: 15/25124-0 - Efeito das propriedades antimicrobianas e citotóxicas de superfícies de titânio revestidas com microcristais de ±-Ag2WO4 e -Ag2MoO4
• Beneficiário: Carlos Eduardo Vergani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/13834-2 - Avaliação da atividade antifúngica e citotoxicidade de microcristais de alfa vanadato de prata (a-AgVO3) sintetizados em diferentes temperaturas
• Beneficiário: Bruna Natalia Alves da Silva Pimentel
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/00317-4 - Modificação da superfície da liga Ti-15Mo para liberação de medicamentos
• Beneficiário: André Luiz Reis Rangel
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 15/26273-9 - Modificação da superfície da liga Ti-15Mo para liberação de medicamentos
• Beneficiário: André Luiz Reis Rangel
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto