Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration

Autor(es)

Pimentel Lopes de Oliveira, Guilherme Jose ^[1] ; Tinajero Aroni, Mauricio Andres ^[2] ; Pinotti, Felipe Eduardo ^[2] ; Marcantonio Jr, Elcio ; Chierici Marcantonio, Rosemary Adriana ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Uberlandia, Dent Sch, Dept Periodontol, Para Av 1720, BR-38400902 Uberlandia, MG - Brazil

^[2] Sao Paulo State Univ, Dept Diag & Surg, Sch Dent, UNESP, Campus Araraquara, Humaita St 1680, BR-14801903 Araraquara, SP - Brazil

^[3] Marcantonio Jr, Jr., Elcio, Sao Paulo State Univ, Dept Diag & Surg, Sch Dent, UNESP, Campus Araraquara, Humaita St 1680, BR-14801903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 35, n. 7 FEB 2020.
• Citações Web of Science: 0

Resumo

The aim of this study was to evaluate the osseointegration of implants placed in areas grafted with different osteoconductive bone substitutes irradiated with infrared low-level laser therapy (LLLT). Fifty-six rats were randomly allocated into 4 groups: DBB, bone defects filled with deproteinized bovine bone graft (DBB); HA/TCP, bone defects filled with biphasic ceramic made of hydroxyapatite and beta-tricalcium phosphate (HA/TCP); DBB-L, bone defects filled with DBB and treated by LLLT; HA/TCP-L, bone defects filled with HA/TCP and treated by LLLT. Bone defects were performed in the tibia of each animal and filled with the different biomaterials. The grafted areas were treated with LLLT (lambda 808 nm, 100 mW, phi similar to 0.60 mm) in 7 sessions with 48 h between the irradiations. After the 60-day period, the implants were placed, and the animals were euthanized after 15 and 45 days. The osseointegration and bone repair in the grafted area were evaluated by biomechanical, microtomographic and histometric analyses, and the expression of some bone biomarkers was evaluated by immunohistochemistry analysis. LLLT induced higher degree of osseointegration, which was associated with the greater expression of BMP2 and OCN. LLLT performed in areas grafted with osteoconductive bone substitutes prior to implant placement improves osseointegration. (AU)

• Processo FAPESP: 13/24318-0 - Efeito da irradiação com laser de baixa intensidade (830nm) sobre a osseointegração de implantes em regiões enxertadas com diferentes biomateriais osteocondutores
• Beneficiário: Guilherme José Pimentel Lopes de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado