| Texto completo | |
| Autor(es): |
Zabihi, Azam
[1]
;
Tello, John
[2]
;
Incerti, Sebastien
[3, 4]
;
Francis, Ziad
[5]
;
Forozani, Ghasem
[6]
;
Semsarha, Farid
[7]
;
Moslehi, Amir
[8]
;
Bernal, Mario A.
[2]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Bu Ali Sina Univ, Fac Sci, Dept Phys, Hamadan, Hamadan - Iran
[2] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Campinas - Brazil
[3] Univ Bordeaux, CENBG, UMR 5797, F-33170 Gradignan - France
[4] CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan - France
[5] Univ St Joseph, Fac Sci, Dept Phys, Beirut - Lebanon
[6] Payame Noor Univ, Dept Phys, POB 19395-3697, Tehran - Iran
[7] Univ Tehran, Inst Biochem & Biophys, POB 13145-1384, Tehran - Iran
[8] Nucl Sci & Technol Res Inst, Radiat Applicat Res Sch, POB 11365-3486, Tehran - Iran
Número total de Afiliações: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Applied Radiation and Isotopes; v. 156, FEB 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
This work presents a model previously developed for estimating relative biological effectiveness (RBE) associated with high-LET particles. It is based on the combination of Monte Carlo simulations of particle interactions when traversing an atomic resolution DNA geometrical model. In addition, the model emulates the induction of lethal damage from the interaction of two sublethal lesions, taken as double-strand breaks. The Geant4-DNA package was used for simulations with liquid water as the transport medium. The RBE of neutron beams with energies ranging from 0.1 MeV up to 14 MeV was studied. The model succeeded in reproducing the general behavior of RBE as a function of neutron energy, including the RBE peak reported by experiments at approximately 0.4 MeV. Furthermore, the results of the model agree rather well with some experimental works. However, our results underestimate RBE for neutron energies above approximately 5 MeV due to the current limitations of Geant4-DNA for the tracking of heavy ions below 0.5 MeV/u. (AU) | |
| Processo FAPESP: | 11/51594-2 - Desenvolvimento de um sistema computacional para a simulação da interação da radiação ionizante com o material genético humano |
| Beneficiário: | Mario Antonio Bernal Rodriguez |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 18/15316-7 - Estudo da interação de partículas carregadas pesadas com o DNA usando métodos computacionais |
| Beneficiário: | Mario Antonio Bernal Rodriguez |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 15/21873-8 - Desenvolvimento e implementação de metodologias para otimização de técnicas de imagens em radiologia digital |
| Beneficiário: | Alessandra Tomal |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |