Green tea supplementation improves oxidative stress biomarkers and modulates IL-6 circulating levels in obese women

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Natália Y Noronha ^[1] ; Marcela A Souza Pinhel ^[2] ; Carolina F Nicoletti ^[3] ; Driele C Quinhoneiro ^[4] ; Vitor C Pinhanelli ^[5] ; Bruno A P de Oliveira ^[6] ; Cristina Cortes-Oliveira ^[7] ; Heitor B P Delfino ^[8] ; Letícia S Wolf ^[9] ; Fabiani G Frantz ^[10] ; Julio S Marchini ^[11] ; Carla B Nonino ^[12]

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^[1] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[2] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[3] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[4] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[5] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[6] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[7] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[8] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[9] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[10] University of São Paulo. Ribeirão Preto Medical School. Department of Clinical Toxicological and Bromatological Analysis - Brasil

^[11] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

^[12] University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine - Brasil

• Tipo de documento: Artigo Científico
• Fonte: NUTRICION HOSPITALARIA; v. 36, n. 3, p. 583-588, 2020-02-10.

Resumo

Abstract Introduction: obesity is associated with high levels of oxidative stress (OS) and inflammation. There is a lot of evidence that some polyphenols, such as green tea, have a positive impact on the OS state and consecutively, on inflammation. Objectives: the purposes of this study were: a) evaluate OS biomarkers in both obese and normal weight women; and b) evaluate if green tea supplementation has an impact on OS and inflammatory cytokine biomarkers of obese women. Methods: we evaluated obese (body mass index [BMI] ≥ 40 kg/m²) and normal weight (BMI between 18.5 and 24.9 kg/m²) women. Blood samples were used to access malondialdehyde (MDA), trolox equivalent antioxidant capacity (TEAC) and inflammatory cytokines. We randomly chose obese patients (18 individuals) and then gave them green tea supplementation for eight weeks. Statistical analysis included the Shapiro-Wilk, Wilcoxon, independent and paired t tests; p < 0.05 were considered as significant. Results: we enrolled 42 obese (BMI: 48.2 ± 9.3kg/m2) and 21 normal weight (BMI: 22.5 ± 2 kg/m2) women with an average age of 36.2 ± 9.1 years old. The serum levels of MDA were higher in obese (2.52 ± 0.31 µmol/l) than in eutrophic women (2.13 ± 0.26 µmol/l; p = 0.000). On the other hand, lower TEAC values were observed in the obese (0.75 ± 0.06 mM/l) than in the eutrophic group (0.78 ± 0.04 mM/l; p = 0.009). After the green tea intervention, MDA decreased 4.7% and TEAC increased 10%. Interleukin-6 (IL-6) serum levels decreased 12.7% after treatment (p = 0.03). Conclusions: a) the obese group had lower antioxidant capacity than eutrophic; and b) green tea supplementation ameliorated TEAC and MDA and reduced serum levels of IL-6 in obese women. (AU)

• Processo FAPESP: 14/16740-6 - Expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após intervenções para perda de peso
• Beneficiário: Natália Yumi Noronha
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 13/08916-4 - Análise da expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após intervenções para perda de peso
• Beneficiário: Carla Barbosa Nonino
• Modalidade de apoio: Auxílio à Pesquisa - Regular