| Texto completo | |
| Autor(es): |
de Oliveira, Daniel Minutti
[1]
;
Junqueira Vasques, Ana Carolina
[2, 1]
;
Goncalves, Ezequiel Moreira
[3]
;
Valente de Lemos-Marini, Sofia Helena
[4]
;
Guerra-Junior, Gil
[3]
;
Geloneze, Bruno
[1, 5]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Lab Invest Metab & Diabet, LIMED, Gastroctr, UNICAMP, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, Limeira, SP - Brazil
[3] Univ Estadual Campinas, Lab Growth & Dev LabCreD, Ctr Invest Pediat CIPED, Sch Med Sci, Campinas - Brazil
[4] Univ Estadual Campinas, Sch Med Sci, Dept Paediat, Campinas, SP - Brazil
[5] Univ Estadual Campinas, OCRC, Inst Biol, Sao Paulo - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ENDOCRINE PRACTICE; v. 26, n. 4, p. 388-398, APR 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Objective: To characterize resting energy expenditure (REE) in patients with classic 21-hydroxylase congenital adrenal hyperplasia (21-OH CAH) using indirect calorimetry and compare it to the most commonly used REE predictive equations. Methods: This case-control study comprised 29 post-pubertal 21-OH CAH patients regularly followed at the University of Campinas. Elevated serum 17-hydroxyprogesterone and CYP21 gene molecular analysis confirmed the diagnosis. A healthy control group paired by age, gender, and body mass index was examined. Dual-energy X-ray absorptiometry (DEXA) measured body compositions. A bioimpedance analyzer determined fat-free mass, and indirect calorimetry using a metabolic cart measured REE. Results: Unlike our initial hypothesis, REE was similar between the groups (18.7 3.1 kcal/kg/day in CAH vs. 20.3 3.5 kcal/kg/day in controls; P = .728). No predictive equations reached the stipulated accuracy criteria, thus lacking validity in REE assessment in adults with the characteristics of the group studied. DEXA analysis revealed higher body fat and diminished nonbone lean mass in 21-OH CAH. Anthropometric and bioelectrical impedance parameters were not significantly different. Conclusion: Classic 21-OH CAH is generally followed in reference centers, which may facilitate indirect calorimetry use for REE measurement. Alternatively, considering our REE findings in adult 21-OH CAH patients, nutrition management based on 25 kcal/body weight/day (measured REE x activity factor 1.2 to 1.3) may be reasonable for current body weight maintenance in these patients. (AU) | |
| Processo FAPESP: | 12/16778-8 - Avaliação cardiometabólica e do padrão de secreção de células beta pancreáticas em pacientes portadores de hiperplasia adrenal congênita |
| Beneficiário: | Gil Guerra Júnior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/23460-1 - Risco cardiometabólico em pacientes com a forma clássica da Hiperplasia Adrenal Congênita por deficiência da enzima 21-hidroxilase. |
| Beneficiário: | Ezequiel Moreira Gonçalves |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |