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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ENERGY EXPENDITURE IN 21-HYDROXYLASE CONGENITAL ADRENAL HYPERPLASIA PATIENTS AND COMPARISON WITH PREDICTIVE EQUATIONS

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Author(s):
de Oliveira, Daniel Minutti [1] ; Junqueira Vasques, Ana Carolina [2, 1] ; Goncalves, Ezequiel Moreira [3] ; Valente de Lemos-Marini, Sofia Helena [4] ; Guerra-Junior, Gil [3] ; Geloneze, Bruno [1, 5]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Lab Invest Metab & Diabet, LIMED, Gastroctr, UNICAMP, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, Limeira, SP - Brazil
[3] Univ Estadual Campinas, Lab Growth & Dev LabCreD, Ctr Invest Pediat CIPED, Sch Med Sci, Campinas - Brazil
[4] Univ Estadual Campinas, Sch Med Sci, Dept Paediat, Campinas, SP - Brazil
[5] Univ Estadual Campinas, OCRC, Inst Biol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: ENDOCRINE PRACTICE; v. 26, n. 4, p. 388-398, APR 2019.
Web of Science Citations: 0
Abstract

Objective: To characterize resting energy expenditure (REE) in patients with classic 21-hydroxylase congenital adrenal hyperplasia (21-OH CAH) using indirect calorimetry and compare it to the most commonly used REE predictive equations. Methods: This case-control study comprised 29 post-pubertal 21-OH CAH patients regularly followed at the University of Campinas. Elevated serum 17-hydroxyprogesterone and CYP21 gene molecular analysis confirmed the diagnosis. A healthy control group paired by age, gender, and body mass index was examined. Dual-energy X-ray absorptiometry (DEXA) measured body compositions. A bioimpedance analyzer determined fat-free mass, and indirect calorimetry using a metabolic cart measured REE. Results: Unlike our initial hypothesis, REE was similar between the groups (18.7 3.1 kcal/kg/day in CAH vs. 20.3 3.5 kcal/kg/day in controls; P = .728). No predictive equations reached the stipulated accuracy criteria, thus lacking validity in REE assessment in adults with the characteristics of the group studied. DEXA analysis revealed higher body fat and diminished nonbone lean mass in 21-OH CAH. Anthropometric and bioelectrical impedance parameters were not significantly different. Conclusion: Classic 21-OH CAH is generally followed in reference centers, which may facilitate indirect calorimetry use for REE measurement. Alternatively, considering our REE findings in adult 21-OH CAH patients, nutrition management based on 25 kcal/body weight/day (measured REE x activity factor 1.2 to 1.3) may be reasonable for current body weight maintenance in these patients. (AU)

FAPESP's process: 12/16778-8 - Cardiometabolic evaluation and pancreatic beta cell secretion pattern in congenital adrenal hyperplasia patients
Grantee:Gil Guerra Júnior
Support type: Regular Research Grants
FAPESP's process: 11/23460-1 - Cardiometabolic risk in patients with classical Congenital Adrenal Hyperplasia due to 21-hydroxylase deficiency.
Grantee:Ezequiel Moreira Gonçalves
Support type: Scholarships in Brazil - Post-Doctorate