Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Scaffolds of PCL combined to bioglass: synthesis, characterization and biological performance

Texto completo
Autor(es):
da Fonseca, Gabriela Fernandes [1] ; Marco Avelino, Sarah de Oliveira [2] ; Reis Mello, Daphne de Camargo [2] ; do Prado, Renata Falchete [1] ; Bastos Campos, Tiago Moreira [3] ; Reis de Vasconcellos, Luana Marotta [2] ; Triches, Eliandra de Sousa [4] ; Souto Borges, Alexandre Luiz [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Inst Sci & Technol Sao Jose dos Campos, Dept Dent Mat & Prosthodont, Av Engenheiro Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Sci & Technol Sao Jose dos Campos, Dept Biosci & Oral Diag, Av Engenheiro Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[3] Technol Inst Aeronaut ITA, Praca Marechal Eduardo Gomes, 50 Vila Acacias, BR-12228900 Sao Jose Dos Campos, SP - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Bioceram Lab BIOCERAM, Av Cesare Monsueto Giulio Lattes 1201, BR-12247014 Sao Jose Dos Campos, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE; v. 31, n. 5 APR 29 2020.
Citações Web of Science: 0
Resumo

Biomaterials may be useful in filling lost bone portions in order to restore balance and improve bone regeneration. The objective of this study was to produce polycaprolactone (PCL) membranes combined with two types of bioglass (Sol-Gel and melt-quenched) and determine their physical and biological properties. Membranes were produced through electrospinning. This study presented three experimental groups: pure PCL membranes, PCL-Melt-Bioglass and PCL-Sol-gel-Bioglass. Membranes were characterized using Scanning Electron Microscopy, Fourier Transform Infrared Spectrophotometry (FTIR), Energy-Dispersive Spectroscopy and Zeta Potential. The following in vitro tests were performed: MTT assay, alkaline phosphatase activity, total protein content and mineralization nodules. Twenty-four male rats were used to observe biological performance through radiographic, fracture energy, histological and histomorphometric analyses. The physical and chemical analysis results showed success in manufacturing bioactive membranes which significantly enhanced cell viability and osteoblast differentiation. The new formed bone from the in vivo experiment was similar to that observed in the control group. In conclusion, the electrospinning enabled preparing PCL membranes with bioglass incorporated into the structure and onto the surface of PCL fibers. The microstructure of the PCL membranes was influenced by the bioglass production method. Both bioglasses seem to be promising biomaterials to improve bone tissue regeneration when incorporated into PCL. {[}GRAPHICS] . (AU)

Processo FAPESP: 17/04389-0 - Efeito modulador da radiação ionizante sobre citocinas sanguíneas em ratos submetidos a cirurgia de implantes
Beneficiário:Sarah de Oliveira Marco Avelino
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica