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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Scaffolds of PCL combined to bioglass: synthesis, characterization and biological performance

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Author(s):
da Fonseca, Gabriela Fernandes [1] ; Marco Avelino, Sarah de Oliveira [2] ; Reis Mello, Daphne de Camargo [2] ; do Prado, Renata Falchete [1] ; Bastos Campos, Tiago Moreira [3] ; Reis de Vasconcellos, Luana Marotta [2] ; Triches, Eliandra de Sousa [4] ; Souto Borges, Alexandre Luiz [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Sci & Technol Sao Jose dos Campos, Dept Dent Mat & Prosthodont, Av Engenheiro Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Sci & Technol Sao Jose dos Campos, Dept Biosci & Oral Diag, Av Engenheiro Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[3] Technol Inst Aeronaut ITA, Praca Marechal Eduardo Gomes, 50 Vila Acacias, BR-12228900 Sao Jose Dos Campos, SP - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Bioceram Lab BIOCERAM, Av Cesare Monsueto Giulio Lattes 1201, BR-12247014 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE; v. 31, n. 5 APR 29 2020.
Web of Science Citations: 0
Abstract

Biomaterials may be useful in filling lost bone portions in order to restore balance and improve bone regeneration. The objective of this study was to produce polycaprolactone (PCL) membranes combined with two types of bioglass (Sol-Gel and melt-quenched) and determine their physical and biological properties. Membranes were produced through electrospinning. This study presented three experimental groups: pure PCL membranes, PCL-Melt-Bioglass and PCL-Sol-gel-Bioglass. Membranes were characterized using Scanning Electron Microscopy, Fourier Transform Infrared Spectrophotometry (FTIR), Energy-Dispersive Spectroscopy and Zeta Potential. The following in vitro tests were performed: MTT assay, alkaline phosphatase activity, total protein content and mineralization nodules. Twenty-four male rats were used to observe biological performance through radiographic, fracture energy, histological and histomorphometric analyses. The physical and chemical analysis results showed success in manufacturing bioactive membranes which significantly enhanced cell viability and osteoblast differentiation. The new formed bone from the in vivo experiment was similar to that observed in the control group. In conclusion, the electrospinning enabled preparing PCL membranes with bioglass incorporated into the structure and onto the surface of PCL fibers. The microstructure of the PCL membranes was influenced by the bioglass production method. Both bioglasses seem to be promising biomaterials to improve bone tissue regeneration when incorporated into PCL. {[}GRAPHICS] . (AU)

FAPESP's process: 17/04389-0 - Modulator effect of ionizing radiation on blood cytokines in rats submitted to implants surgery
Grantee:Sarah de Oliveira Marco Avelino
Support Opportunities: Scholarships in Brazil - Scientific Initiation