Preparation and Characterization of Stabilizer-Free Phytantriol-Based Water-in-Oil Internally Liquid Crystalline Emulsions

Autor(es)

Akhlaghi, Seyedeh Parinaz ^{[1, 2]} ; da Silveira Balestrin, Lia Beraldo ^[1] ; Brinatti, Cesar ^[1] ; Pirolt, Franz ^[3] ; Loh, Watson ^[1] ; Glatter, Otto ^[3]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil

^[2] Univ Toronto, Dept Chem Engn & Appl Chem, Fac Appl Sci & Engn, 160 Coll St, Toronto, ON M5S 3E1 - Canada

^[3] Graz Univ Technol, Inst Chem & Technol Mat, Stremayrgasse 9, A-8010 Graz - Austria

• Tipo de documento: Artigo Científico
• Fonte: Journal of Pharmaceutical Sciences; v. 109, n. 6, p. 2024-2032, JUN 2020.
• Citações Web of Science: 0

Resumo

Despite the widespread use of surfactants, there are known issues such as allergic reactions and formulation complications in their use as emulsion stabilizers. In this study, stabilizer-free water-in-oil (W/O) emulsions containing water, phytantriol, and almond oil were prepared by an ultra-turrax homogenizer, a standard laboratory equipment, and a high specialized high-shear device. Parameters such as mixing time, stirring rate, composition, order of addition of phases, and temperature were investigated to systematically optimize the preparation of the formulations through evaluating their accelerated physical stability by a centrifugal sedimentation technique. The liquid crystalline structure of the continuous phase was studied by small-angle X-ray scattering indicating a reverse hexagonal phase (H-2). Microscopy images showed the emulsions prepared via high-shear method had smaller water droplets with more uniform shape and better dispersion as confirmed by Fourier-transform infrared-attenuated total reflection spectroscopy. Rheology studies showed a larger yield stress value for emulsions with higher content of phytantriol. Our results indicated that emulsions prepared by the high-shear device with higher amount of phytantriol were the most stable formulations. Applying the correct variables in the preparation of the stabilizer-free emulsions using ultra-turrax homogenizer, one could obtain similarly stable emulsions lacking the uniformity of the droplets. (C) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 17/03950-0 - Preparação de emulsões de água em óleo livres de surfactantes para aplicações cosmeceuticas
• Beneficiário: Seyedeh Parinaz Akhlaghi
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 14/24305-8 - Máscaras de Celulose Bacteriana Carregadas com Cubossomas contendo o Peptídeo Pal-KTTKS: Um Sistema Multifuncional de Cuidados com a Pele
• Beneficiário: Seyedeh Parinaz Akhlaghi
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado