Water-soluble poly(N-isopropylacrylamide) nanoparticles grafted to trivalent lanthanide complexes as highly sensitive ratiometric nanothermometers

Autor(es)

Sobrinho, Josiane Aparecida ^[1] ; Brito Junior, Gilmar Araujo ^[1] ; Mazali, Italo Odone ^[1] ; Sigoli, Fernando Aparecido ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Lab Funct Mat, Inst Chem, POB 6154, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEW JOURNAL OF CHEMISTRY; v. 44, n. 19, p. 8068-8075, MAY 21 2020.
• Citações Web of Science: 0

Resumo

Nanothermometry became a very active research field, particularly in the biomedical area, given the interrelationship between abnormal temperatures and pathological conditions, as well as the development of heating-mediated therapies. In order to provide an accurate assessment of temperature in the submicron range, several thermosensitive optical materials have been developed. In this work, a new water-soluble, optical ratiometric nanothermometer, composed of pNIPAM nanoparticles grafted to lanthanide complexes, was designed and synthesized. A chelator monomer derivative of dipicolinic acid was successfully synthesized and incorporated into the pNIPAM network through free radical emulsion polymerization. The further coordination of trivalent lanthanide ions (Ln(III) = Tb and/or Eu) to the obtained nanoparticles yielded luminescent thermosensitive polymers with a tunable temperature-responsive range, depending on the adopted synthesis conditions. A synergy between the pNIPAM thermosensitive response and the susceptibility of the lanthanide ion emission to be suppressed through multiphonon relaxation was explored, giving rise to optical temperature probes with reversible response, high relative thermal sensitivity, low temperature uncertainties, and excellent repeatability in aqueous solution. The obtained results indicate that the system has great potential for temperature probing in aqueous media, showing one of the highest relative thermal sensitivities so far described in the literature for water-soluble, lanthanide-based systems with ratiometric response within the biological temperature range. (AU)

• Processo FAPESP: 14/50906-9 - INCT 2014: em Materiais Complexos Funcionais (INOMAT)
• Beneficiário: Fernando Galembeck
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/22127-2 - Desenvolvimento de novos materiais estratégicos para dispositivos analíticos integrados
• Beneficiário: Lauro Tatsuo Kubota
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/22426-5 - Síntese de complexos de lantanídeos com potenciais aplicações como marcadores luminescentes e catalisadores assimétricos em síntese orgânica
• Beneficiário: Gilmar Araujo Brito Junior
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado