The Relationship of IL-8 and IL-10 Myokines and Performance in Male Marathon Runners Presenting Exercise-Induced Bronchoconstriction

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Batista dos Santos, Juliana de Melo ^[1] ; Lacerda Bachi, Andre Luis ^{[2, 1]} ; Luna Junior, Luiz Antonio ^[1] ; Foster, Roberta ^{[1, 3]} ; Renno Sierra, Ana Paula ^[4] ; Benetti, Marino ^[4] ; Araujo, Jose Roberto ^[5] ; Ghorayeb, Nabil ^[6] ; Dal'Molim Kiss, Maria Augusta Peduti ^[4] ; Vieira, Rodolfo P. ^{[7, 8, 9, 10]} ; Bullens, Dominique M. A. ^{[11, 12]} ; Vaisberg, Mauro ^[1]

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^[1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, ENT Lab, BR-04025002 Sao Paulo - Brazil

^[2] Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, BR-04829300 Sao Paulo - Brazil

^[3] Method Fac Sao Paulo FAMESP, BR-04046200 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil

^[5] Fed Univ Sao Paulo UNIFESP, Dept Morphol & Genet, BR-04023900 Sao Paulo - Brazil

^[6] Dante Pazzanese Inst Cardiol, Sports Cardiol Dept, BR-04012909 Sao Paulo - Brazil

^[7] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, BR-11060001 Santos, SP - Brazil

^[8] Brazilian Inst Teaching & Res Pulm & Exercise Imm, BR-12245520 Sao Jose Dos Campos - Brazil

^[9] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, BR-08230030 Sao Paulo - Brazil

^[10] Anhembi Morumbi Univ, Sch Med, BR-04705000 Sao Jose Dos Campos - Brazil

^[11] UZ Leuven, Clin Div Pediat, B-3000 Leuven - Belgium

^[12] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Allergy & Clin Immunol Res Grp, B-3000 Leuven - Belgium

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; v. 17, n. 8 APR 2020.
• Citações Web of Science: 0

Resumo

At present, it is unclear which exercise-induced factors, such as myokines, could diminish the negative impact of the reduction in pulmonary function imposed by the exercise in question. In this study, we aim to evaluate the prevalence of exercise-induced bronchoconstriction (EIB) and also to investigate the effect of myokines in the performance of marathon runners presenting EIB or not. Thirty-eight male recreational marathon runners (age 38.8 {[}33-44], height 175.7 {[}172.0-180.3]; weight 74.7 {[}69.3-81.6]) participated in this study, and through spirometry tests, a prevalence of 23.6% of EIB was found, which is in agreement with the literature. The volunteers who tested positive to EIB (EIB+) presented lower maximum aerobic capacity compared to those who tested negative (EIB-) (EIB+ 44.02 {[}39.56-47.02] and EIB- 47.62 {[}44.11-51.18] p = 0.03). The comparison of plasma levels of IL-1 beta (EIB+ p = 0.296, EIB- p = 0.176, EIB+ vs. EIB- baseline p = 0.190 immediately after p = 0.106), IL-4 (undetectable), IL-6 (EIB+ p = 0.003, EIB- p <= 0.001, EIB+ vs. EIB- baseline p = 0.301 immediately after p = 0.614), IL-8 (EIB+ p = 0.003, EIB- p <= 0.001, EIB+ vs. EIB- baseline p = 0.110 immediately after p = 0.453), IL-10 (EIB+ p = 0.003, EIB- p <= 0.001, EIB+ vs. EIB- baseline p = 0.424 immediately after p = 0.876) and TNF-alpha (EIB+ p = 0.003, EIB- p <= 0.001, EIB+ vs. EIB- baseline p = 0.141 immediately after p = 0.898) were similar in both groups 24 h before and immediately after the marathon. However, negative correlations were found between the marathon finishing time and the levels of IL-8 (r = -0.81, p = 0.022), and IL-10 (r = -0.97, p <= 0.001) immediately after completing the marathon. In conclusion, for the first time, it is shown that the myokines IL-8 and IL-10 are related to improvement of the performance of marathon runners presenting EIB. (AU)

• Processo FAPESP: 12/51698-5 - Influência da economia de corrida sobre o perfil imunológico e oxidativo de maratonistas
• Beneficiário: Mauro Walter Vaisberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/15165-2 - Papel da sinalização purinérgica e da sinalização SOCS-JAK-STAT nos efeitos antiinflamatórios do treinamento aeróbio em modelos experimentais de asma e em indivíduos asmáticos
• Beneficiário: Rodolfo de Paula Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores