Laser-induced breakdown spectroscopy as a tool for homogeneity measurements in medicine tablets

Autor(es)

Zanetti, T. C. ^[1] ; Catelani, T. A. ^[2] ; Pereira-Filho, E. R. ^[2] ; Cabral, J. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Uberlandia, Inst Fis, BR-38400902 Uberlandia, MG - Brazil

^[2] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Laser Physics; v. 30, n. 3 MAR 2020.
• Citações Web of Science: 0

Resumo

In this work, we have used laser-induced breakdown spectroscopy (LIBS) in the analysis of commercial tablets. The samples were mainly composed of dipyrone, an analgesic and fever reliever consumed worldwide. At first, the physical parameters, temperature and electronic density of the plasma were calculated throughout the Boltzmann plot and Saha equation respectively, and the McWhirter criterion was achieved, which allows us to assert that the minimum criterion for local thermodynamic equilibrium is presented in the plasma generated. After that, the tablets' homogeneity was assessed using the whole LIBS spectra combined to correlation statistic methods, such as principal components analysis (PCA) and hyperspectral images. The results show high homogeneity, R > 0.996, at the surface and some heterogeneity in the bulk. LIBS was also applied for major active pharmaceutical ingredients C, Na and Mg identification. (AU)

• Processo FAPESP: 16/01513-0 - Combinação de LIBS (Laser-Induced Breakdown Spectroscopy) e ICP OES (Inductively Coupled Plasma Optical Emission Spectrometry) na análise de amostras de resíduo eletrônico (circuito eletrônico e polímeros), alimentos e líquidas de difícil preparação
• Beneficiário: Edenir Rodrigues Pereira Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular