Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings

Autor(es)

Bitencourt, Flavia B. C. S. N. ^[1] ; Bitencourt, V, Almir G. ; Chojniak, Martha M. M. ^[2] ; Souza, Juliana O. ^[3] ; Castro, Douglas G. ^[4] ; Pellizzon, Antonio Cassio A. ^[4] ; Chojniak, Rubens ^[3]

Afiliação do(s) autor(es)

^[1] Fleury Med & Saude, Diagnost Ctr Ophthalmol, Sao Paulo - Brazil

^[2] AC Camargo Canc Ctr, Ophthalmol Dept, Sao Paulo - Brazil

^[3] Bitencourt, Almir G., V, AC Camargo Canc Ctr, Imaging Dept, Sao Paulo - Brazil

^[4] AC Camargo Canc Ctr, Radiat Oncol Dept, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN ONCOLOGY; v. 10, MAY 19 2020.
• Citações Web of Science: 0

Resumo

Purpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the assessment of therapeutic response in patients with choroidal melanoma treated with brachytherapy. Materials and Methods: We performed a prospective, unicentric study which included patients with choroidal melanoma and indication for brachytherapy. Three DW-MRI examinations were proposed for each patient, one before and two after treatment. The apparent diffusion coefficient (ADC) value was calculated on DW-MRI and compared with local tumor control assessed by ophthalmologic follow-up. Results: From 07/2018 to 06/2019, 19 patients were recruited, 13 of whom underwent follow-up examinations. Patients' ages ranged from 24 to 78 years and 52.9% were male. At the ocular ultrasound, the mean tumor thickness and diameter were 6.3 and 11.5 mm, respectively. Two patients (15.4%) showed signs of tumor progression during follow-up (7 and 9 months after treatment). There was no statistically significant difference in tumor size between MR before and after treatment, however, there was a significant reduction in mean ADC in patients with progression (p = 0.02). Conclusion: DW-MRI is a promising method for monitoring patients with choroidal melanoma; reduction in the mean ADC values between pre-treatment MRI and the first post-treatment MRI may be related to the lack of response to brachytherapy and increased risk of disease progression. (AU)

• Processo FAPESP: 16/05967-5 - Ressonância magnética com difusão na avaliação de pacientes com melanoma de coroide submetidos a braquiterapia.
• Beneficiário: Almir Galvão Vieira Bitencourt
• Modalidade de apoio: Auxílio à Pesquisa - Regular