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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings

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Author(s):
Bitencourt, Flavia B. C. S. N. [1] ; Bitencourt, V, Almir G. ; Chojniak, Martha M. M. [2] ; Souza, Juliana O. [3] ; Castro, Douglas G. [4] ; Pellizzon, Antonio Cassio A. [4] ; Chojniak, Rubens [3]
Total Authors: 7
Affiliation:
[1] Fleury Med & Saude, Diagnost Ctr Ophthalmol, Sao Paulo - Brazil
[2] AC Camargo Canc Ctr, Ophthalmol Dept, Sao Paulo - Brazil
[3] Bitencourt, Almir G., V, AC Camargo Canc Ctr, Imaging Dept, Sao Paulo - Brazil
[4] AC Camargo Canc Ctr, Radiat Oncol Dept, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: FRONTIERS IN ONCOLOGY; v. 10, MAY 19 2020.
Web of Science Citations: 0
Abstract

Purpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the assessment of therapeutic response in patients with choroidal melanoma treated with brachytherapy. Materials and Methods: We performed a prospective, unicentric study which included patients with choroidal melanoma and indication for brachytherapy. Three DW-MRI examinations were proposed for each patient, one before and two after treatment. The apparent diffusion coefficient (ADC) value was calculated on DW-MRI and compared with local tumor control assessed by ophthalmologic follow-up. Results: From 07/2018 to 06/2019, 19 patients were recruited, 13 of whom underwent follow-up examinations. Patients' ages ranged from 24 to 78 years and 52.9% were male. At the ocular ultrasound, the mean tumor thickness and diameter were 6.3 and 11.5 mm, respectively. Two patients (15.4%) showed signs of tumor progression during follow-up (7 and 9 months after treatment). There was no statistically significant difference in tumor size between MR before and after treatment, however, there was a significant reduction in mean ADC in patients with progression (p = 0.02). Conclusion: DW-MRI is a promising method for monitoring patients with choroidal melanoma; reduction in the mean ADC values between pre-treatment MRI and the first post-treatment MRI may be related to the lack of response to brachytherapy and increased risk of disease progression. (AU)

FAPESP's process: 16/05967-5 - DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING IN THE EVALUATION OF PATIENTS WITH CHOROIDAL MELANOMA TREATED WITH BRACHYTHERAPY.
Grantee:Almir Galvão Vieira Bitencourt
Support Opportunities: Regular Research Grants