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Diffusion-weighted magnetic resonance imaging in the pilocarpine model of temporal lobe epilepsy

Grant number: 17/25029-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 01, 2018
Effective date (End): March 31, 2019
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Fernando Cendes
Grantee:Renata Barbosa
Supervisor abroad: Luis Concha Loyola
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Local de pesquisa : Universidad Nacional Autónoma de México, Juriquilla (UNAM), Mexico  
Associated to the scholarship:14/11277-6 - Structural and biochemical evaluation by magnetic resonance imaging in temporal lobe epilepsy model in rats with and without status epilepticus, BP.DR

Abstract

Epileptogenesis is defined as a chronic process triggered by genetic or acquired factors in which the brain network becomes susceptible to seizures and predisposed to generate spontaneous recurrent seizures. However, the concept of epileptogenesis is not yet well established. Brain trauma, injury during early childhood and birth, stroke, infections, status epilepticus, and tumor are risk factors related to epileptogenic mechanisms. Studies in humans and animal models of epilepsy have used Diffusion Tensor Imaging (DTI) as an essential tool in the investigation of the epileptogenic process. Although historically epilepsy is considered a disease that affects gray matter, studies have shown that white matter structures, even distant from the initial epileptogenic zone, may also be involved in focal epilepsies. DTI is capable of identifying microstructural changes in the white matter in the brain, such as axonal injury or demyelination through the translational motion of water molecules. This study aims to evaluate microstructural changes in the white matter of the brain of Wistar rats by diffusion-weighted magnetic resonance imaging. The analyses will focus on images made before and during the epileptogenesis latency period, and after the development of spontaneous seizures induced by pilocarpine. Diffusion Tensor Imaging is a promising tool for neuroimaging research in human and animal models. Longitudinal studies with DTI may play a crucial role in the investigation of biomarkers related to the complex mechanisms involved in epileptogenesis, and the experimental models of epilepsy may be an attractive alternative for understanding the epileptogenesis since they show similar characteristics to human epilepsy. (AU)