Artificial intelligence in the IVF laboratory: overview through the application of different types of algorithms for the classification of reproductive data

Autor(es)

Fernandez, Eleonora Inacio ^[1] ; Ferreira, Andre Satoshi ^[1] ; Cecilio, Matheus Henrique Miquelao ^[1] ; Cheles, Doris Spinosa ^{[2, 1]} ; de Souza, Rebeca Colauto Milanezi ^[1] ; Nogueira, Marcelo Fabio Gouveia ^[2] ; Rocha, Jose Celso ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Lab Appl Math, Dept Biol Sci, Campus Assis, Ave Dom Antonio, BR-2100 Sao Paulo, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Biol Sci, Lab Embryon Micromanipulat, Campus Assis, Ave Dom Antonio, BR-2100 Sao Paulo, SP - Brazil

^[3] Univ Estadual Paulista, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS; v. 37, n. 10 JUL 2020.
• Citações Web of Science: 0

Resumo

Over the past years, the assisted reproductive technologies (ARTs) have been accompanied by constant innovations. For instance, intracytoplasmic sperm injection (ICSI), time-lapse monitoring of the embryonic morphokinetics, and PGS are innovative techniques that increased the success of the ART. In the same trend, the use of artificial intelligence (AI) techniques is being intensively researched whether in the embryo or spermatozoa selection. Despite several studies already published, the use of AI within assisted reproduction clinics is not yet a reality. This is largely due to the different AI techniques that are being proposed to be used in the daily routine of the clinics, which causes some uncertainty in their use. To shed light on this complex scenario, this review briefly describes some of the most frequently used AI algorithms, their functionalities, and their potential use. Several databases were analyzed in search of articles where applied artificial intelligence algorithms were used on reproductive data. Our focus was on the classification of embryonic cells and semen samples. Of a total of 124 articles analyzed, 32 were selected for this review. From the proposed algorithms, most have achieved a satisfactory precision, demonstrating the potential of a wide range of AI techniques. However, the evaluation of these studies suggests the need for more standardized research to validate the proposed models and their algorithms. Routine use of AI in assisted reproduction clinics is just a matter of time. However, the choice of AI technique to be used is supported by a better understanding of the principles subjacent to each technique, that is, its robustness, pros, and cons. We provide some current (although incipient) and potential uses of AI on the clinic routine, discussing how accurate and friendly it could be. Finally, we propose some standards for AI research on the selection of the embryo to be transferred and other future hints. For us, the imminence of its use is evident, providing a revolutionary milestone that will impact the ART. (AU)

• Processo FAPESP: 18/24252-2 - Morfocinética associada à inteligência artificial para a predição do blastocisto humano
• Beneficiário: Eleonora Inácio Fernandez
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/19371-2 - Uso de inteligência artificial na predição de nascimentos humanos com base na morfocinética embrionária
• Beneficiário: Matheus Henrique Miquelão Cecilio
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/19323-5 - Classificação de embriões humanos mediante as técnicas de time-lapse, processamento de imagens digitais e inteligência artificial
• Beneficiário: José Celso Rocha
• Modalidade de apoio: Auxílio à Pesquisa - Regular