Genetic variants in tooth agenesis-related genes might be also involved in tooth size variations

Autor(es)

Cunha, Arthur S. ^[1] ; dos Santos, Luiza Vertuan ^[1] ; Maranon-Vasquez, Guido Artemio ^[1] ; Kirschneck, Christian ^[2] ; Gerber, Jennifer Tsi ^[3] ; Stuani, Maria Bernadete ^[1] ; Matsumoto, Mirian Aiko Nakane ^[1] ; Vieira, Alexandre Rezende ^[4] ; Scariot, Rafaela ^[5] ; Kuchler, Erika Calvano ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ave Cafe S-N, Campus USP, BR-4040904 Sao Paulo - Brazil

^[2] Univ Med Ctr Regensburg, Dept Orthodont, Franz Josef Strauss Allee 11, D-93053 Regensburg - Germany

^[3] Posit Univ, Sch Hlth Sci, Curitiba, Parana - Brazil

^[4] Univ Pittsburgh, Sch Dent Med, Dept Oral Biol, 412 Salk Pavil, 335 Sutherland St, Pittsburgh, PA 15261 - USA

^[5] Univ Fed Parana, Dept Stomatol, Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL ORAL INVESTIGATIONS; v. 25, n. 3 JUL 2020.
• Citações Web of Science: 2

Resumo

Objective The present study aimed to evaluate if genetic variants in PAX9, MSX1, TGF alpha, FGF3, FGF10, FGF13, GLI2 and GLI3 are involved in TS of permanent teeth. Materials and methods Pretreatment dental records from orthodontic patients were assessed prior to recruitment. Patients with tooth agenesis and congenital anomalies (including oral cleft) and/or syndromes were excluded. Dental casts were used to measure the maximum crown dimensions of all fully erupted permanent teeth except second and third molars in mesiodistal direction. Teeth with caries, occlusal wear, mesiodistal restorations, and obvious deformities were not evaluated. Genomic DNA samples were used for genotyping. The allelic discrimination of 13 genetic variants was performed. The associations between TS and genotype were analyzed by linear regression, adjusted by gender at a significance level ofp <= 0.05. Results Genetic polymorphisms in the tooth agenesis-related genes studied here were associated with increased and decreased TS, in both maxilla and mandible (p < 0.05). Conclusion This study reported associations of novel tooth agenesis-related gene variants with permanent tooth size variations. (AU)

• Processo FAPESP: 16/08149-1 - Avaliação do papel do estrógeno nos tecidos dentofaciais
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 17/16990-0 - Associação de variações genéticas com alterações esqueléticas dos arcos dentários
• Beneficiário: Guido Artemio Maranon Vasquez
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 18/03533-3 - Associação de variações genéticas em RANK, RANKL e OPG com tamanho dentário
• Beneficiário: Luiza Vertuan dos Santos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica