Patterns of oral mucositis in advanced oral squamous cell carcinoma patients managed with prophylactic photobiomodulation therapy-insights for future protocol development

Autor(es):Mostrar menos -

Paglioni, Mariana de Pauli ^[1] ; Faria, Karina Morais ^[2] ; Palmier, Natalia Rangel ^[1] ; Prado-Ribeiro, Ana Carolina ^{[2, 1]} ; Brito e Dias, Reinaldo ^[3] ; da Graca Pinto, Henrique ^[3] ; Treister, Nathaniel Simon ^{[4, 5]} ; Epstein, Joel B. ^{[6, 7]} ; Migliorati, Cesar Augusto ^[8] ; Santos-Silva, Alan Roger ^[1] ; Brandao, Thais Bianca ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag Dept, UNICAMP, Piracicaba, SP - Brazil

^[2] Sao Paulo State Canc Inst ICESP FMUSP, Dent Oncol Serv, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Bucomaxillofacial Prosthesis, Dent Sch, Sao Paulo - Brazil

^[4] Dana Farber Canc Inst, Boston, MA 02115 - USA

^[5] Brigham & Womens Hosp, Div Oral Med & Dent, 75 Francis St, Boston, MA 02115 - USA

^[6] Cedars Sinai Hosp Syst, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA - USA

^[7] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 - USA

^[8] Univ Florida, Coll Dent, Gainesville, FL - USA

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 36, n. 2 JUL 2020.
• Citações Web of Science: 0

Resumo

To characterize oral sites affected by radiation-induced oral mucositis (OM) and related clinical outcomes in oral cancer patients subjected to prophylactic photobiomodulation therapy (PBMT). This study included advanced oral squamous cell carcinoma (OSCC) patients treated with prophylactic PBMT for OM. The site distribution of OM, OM grading (CTCAE NCI, Version 4.0, 2010), OM-related pain (VAS), analgesic protocol (WHO Analgesic Ladder), and use of enteral nutrition were evaluated weekly during treatment. Data analysis was performed using descriptive statistics expressed as median values and percentages. A total of 145 OSCC patients were included. OM most frequently affected the lateral border of the tongue (44.1%), buccal mucosa (37.2%), and labial mucosa (33.8%). Keratinized oral mucosa sites, including the tongue dorsum (6.21%), retromolar trigone (8.3%), and hard palate (2.76%), were less frequently affected. Peak OM scores were observed at weeks 5, 6, and 7, with severe OM (NCI grades 3 and 4) rates of 11%, 20%, and 25%, respectively. The cumulative occurrence of severe OM was 23%, which developed as early as week 3 and as late as week 7. The highest mean value of OM-related pain (2.7) was observed at the sixth week, and 13.8% of the patients required feeding support. This study showed, compared with studies that did not provide PBMT, reduced severity of mucositis, reduced pain and analgesic use, and reduced tube feeding in patients treated with PBMT. OM involving keratinized and non-keratinized surfaces should be included in the prophylactic PBMT to reduce severe OM in future studies. (AU)

• Processo FAPESP: 12/06138-1 - Estudo prospectivo da incidência de trismo induzido por radioterapia em pacientes com carcinoma espinocelular de boca
• Beneficiário: Ana Carolina Prado Ribeiro e Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/13098-0 - I Seminário de Odontologia Oncológica
• Beneficiário: Ana Carolina Prado Ribeiro e Silva
• Modalidade de apoio: Auxílio Organização - Reunião Científica
• Processo FAPESP: 13/18402-8 - Avaliação dos efeitos diretos da radiação sobre o esmalte, a dentina e a polpa dental de pacientes com câncer de cabeça e pescoço
• Beneficiário: Alan Roger dos Santos Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/04657-8 - Proteínas salivares candidatas a marcadores de toxicidade bucal associada à radioterapia
• Beneficiário: Natália Rangel Palmier
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/02233-6 - Segurança oncológica no uso da fotobiomodulação intraoral e extraoral em pacientes com carcinoma espinocelular de cavidade oral e orofaringe
• Beneficiário: Alan Roger dos Santos Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular