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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Bruxism Throughout the Lifespan and Variants in MMP2, MMP9 and COMT

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Autor(es):
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Vieira, Alexandre R. [1, 2] ; Scariot, Rafaela [3] ; Gerber, Jennifer T. [3] ; Arid, Juliana [4] ; Kuchler, Erika C. [4] ; Sebastiani, Aline M. [3] ; Palinkas, Marcelo [4] ; Diaz-Serrano, V, Kranya ; Torres, Carolina P. [5] ; Regalo, Simone C. H. [6] ; Nelson, Paulo [5] ; Bussaneli, Diego G. [1, 7] ; Deeley, Kathleen [1] ; Modesto, Adriana [1, 2]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Pittsburgh, Dept Oral Biol, Sch Dent Med, 412 Salk Pavil, 335 Sutherland Dr, Pittsburgh, PA 15261 - USA
[2] Univ Pittsburgh, Dept Pediat Dent, Sch Dent Med, Pittsburgh, PA 15213 - USA
[3] Positivo Univ, Dept Oral & Maxillofacial Surg, BR-81280330 Curitiba, Parana - Brazil
[4] Univ Sao Paulo, Dept Pediat Dent, BR-14040904 Ribeirao Preto, SP - Brazil
[5] Diaz-Serrano, Kranya, V, Univ Sao Paulo, Dept Pediat Dent, BR-14040904 Ribeirao Preto, SP - Brazil
[6] Univ Sao Paulo, Dept Morphol Physiol & Basic Pathol, BR-14040904 Ribeirao Preto, SP - Brazil
[7] UNESP, Dept Pediat Dent, BR-14801385 Araraquara, SP - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF PERSONALIZED MEDICINE; v. 10, n. 2 JUN 2020.
Citações Web of Science: 0
Resumo

Bruxism is a masticatory muscle activity characterized by grinding of the teeth and clenching of the jaw that causes tooth wear and breakage, temporomandibular joint disorders, muscle pain, and headache. Bruxism occurs in both adults and children. Clinical characteristics and habits were evaluated in an adult sample. Moreover, we used DNA samples from 349 adults and 151 children to determine the presence of association with specific genes. Genomic DNA was obtained from saliva. The markersrs2241145andrs243832(metalloproteinase 2 (MMP2)),rs13925andrs2236416(metalloproteinase 9 (MMP9)), andrs6269(cathecol-o-methyltransferase (COMT)) were genotyped. Data were submitted to statistical analysis with a significance level of 0.05. In adults, in univariate logistic regression, presence of caries, attrition, and use of alcohol were increased in bruxism individuals (p< 0.05). In addition, in adults, there was an association between bruxism andMMP9(rs13925,p= 0.0001) and bruxism andCOMT(rs6269,p= 0.003). In children, a borderline association was observed forMMP9(rs2236416,p= 0.08). When we performed multivariate logistic regression analyses in adults, the same clinical characteristics remained associated with bruxism, and orthodontic treatment was also associated, besidesrs13925, in the AG genotype (p= 0.015, ORa: 3.40 (1.27-9.07)). For the first time, we provide statistical evidence that these genes are associate with bruxism. (AU)

Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
Beneficiário:Erika Calvano Kuchler
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores