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Physicochemical, antimicrobial, and biological properties of White-MTAFlow

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Pelepenko, Lauter E. [1] ; Saavedra, Flavia [1] ; Antunes, Thiago B. M. [1] ; Bombarda, Gabriela F. [1] ; Gomes, Brenda P. F. A. [1] ; Zaia, Alexandre A. [1] ; Camilleri, Josette [2] ; Marciano, Marina A. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Dent Piracicaba, Dept Restorat Dent, Av Limeira 901, BR-13414903 Piracicaba, SP - Brazil
[2] Univ Birmingham, Coll Med Sci, Dent Sch, Birmingham, W Midlands - England
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Citações Web of Science: 0

Objectives To evaluate a new material containing tantalum oxide as an alternative radiopacifier, and a water-based gel for hydration, in comparison with two calcium silicate-based cement: ProRoot MTA and Biodentine. Materials and methods ProRoot MTA (Dentsply), Biodentine (Septodont), and a new hydraulic calcium silicate cement White-MTAFlow (Ultradent) (in `thin' consistency) were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS). The interaction with dentin was also assessed using SEM and EDS. Physical and chemical properties radiopacity, setting time, linear flow, volumetric central filling, and lateral flow, pH, and volume change were investigated together with the color luminosity (L) and color change (Delta E). The agar diffusion and direct contact antimicrobial activity, and methylthiazolyldiphenyl-tetrazolium-bromide (MTT) cytotoxicity using human fibroblast cells were also evaluated. Data were statistically analyzed at a 5% significance level. Results All materials were composed of tricalcium and dicalcium silicate but had different radiopacifiers, and calcium hydroxide (portlandite) deposition was detected in XRD analysis. White-MTAFlow exhibited radiopacity values in accordance with ISO standard, and the longest setting time. The water-based gel provided the highest linear flow, a comparable cavity central filling, and the highest groove-lateral flow in the volumetric flow analysis. White-MTAFlow exhibited an alkalinity reduction, and Biodentine, a progressive increase of pH values after 28 days. However, similar volume loss for White-MTAFlow was assessed in comparison to Biodentine after the 28-day immersion. White-MTAFlow showed the highest L value (91.5), and ProRoot MTA the lowest (78.1) due to dentin staining caused by bismuth migration. None of the materials exhibited inhibition halos against the tested bacteria, and similar turbidity values were obtained after 48 h in direct contact withE. faecalis, indicating an upregulation to bacterial growth. White-MTAFlow showed MTT cytocompatibility similarly to the control group. Conclusions White-MTAFlow in `thin' consistency presents comparable physicochemical, biological, and antimicrobial properties to ProRoot MTA and Biodentine, and does not cause color alteration in dentin. (AU)

Processo FAPESP: 18/06515-6 - Caracterização química e estrutural de cimentos reparadores de alta plasticidade
Beneficiário:Gabriela Fernanda Bombarda
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 18/06903-6 - Avaliação de propriedades antimicrobianas de cimentos reparadores de alta plasticidade
Beneficiário:Daniel Marioti Secchieri
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 17/05096-7 - Avaliação das propriedades físicas, químicas e antimicrobianas de um novo cimento reparador de alta plasticidade
Beneficiário:Marina Angélica Marciano da Silva
Linha de fomento: Auxílio à Pesquisa - Regular