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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Licochalcone A, a licorice flavonoid: antioxidant, cytotoxic, genotoxic, and chemopreventive potential

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Autor(es):
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de Freitas, Karoline Soares [1] ; Squarisi, Iara Silva [1] ; Acesio, Nathalia Oliveira [1] ; Nicolella, Heloiza Diniz [1] ; Ozelin, Saulo Duarte [1] ; Reis Santos de Melo, Matheus [1] ; Guissone, Ana Paula Prado [1] ; Fernandes, Gabriela [1] ; Silva, Livia Mara [2] ; da Silva Filho, Ademar Alves [2] ; Tavares, Denise Crispim [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Franca, Lab Mutagenese, Franca, SP - Brazil
[2] Univ Fed Juiz de Fora, Fac Farm, Dept Ciencias Farmaceut, Juiz De Fora, MG - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES; v. 83, n. 21-22 SEP 2020.
Citações Web of Science: 2
Resumo

Licochalcone A (LicoA) is a flavonoid derived fromGlycyrrhizaspp. plants. The present study aimed to investigate the antioxidant, cytotoxic, genotoxic, and chemopreventive effects of LicoA inin vitroandin vivosystems. The results showed that LicoA (197.1 mu M) scavenged 77.92% of free radicals. Concentrations of 147.75 mu M or higher LicoA produced cytotoxicity in Chinese hamster ovary (CHO) fibroblasts. LicoA treatments of 4.43 to 10.34 mu M did not exert genotoxic activity, but at 11.8 mu M significantly lowered nuclear division indexes, compared to negative control, revealing cytotoxicity. Lower concentrations (1.85 to 7.39 mu M) exhibited protective activity against chromosomal damage induced by doxorubicin (DXR) or methyl methanesulfonate (MMS) in CHO cells. LicoA exerted no marked influence on DXR-induced genotoxicity in mouse erythrocytes, but reduced pre-neoplastic lesions induced by 1,2-dimethylhydrazine (DMH) in rat colon at 3.12 to 50 mg/kg b.w. Biochemical markers and body weight indicated no apparent toxicity. These findings contribute to better understanding the mechanisms underlying LicoA-initiated activity as a promising chemopreventive compound. (AU)

Processo FAPESP: 17/06070-1 - Licochalcona-A, um flavonoide do alcaçuz: avaliação do potencial quimiopreventivo
Beneficiário:Karoline Soares de Freitas
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 16/22863-9 - Estudo toxicogenético da licochalcona A e de sua influência sobre a instabilidade genômica
Beneficiário:Iara Silva Squarisi
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica