Licochalcone A, a licorice flavonoid: antioxidant, cytotoxic, genotoxic, and chemopreventive potential

Autor(es):Mostrar menos -

de Freitas, Karoline Soares ^[1] ; Squarisi, Iara Silva ^[1] ; Acesio, Nathalia Oliveira ^[1] ; Nicolella, Heloiza Diniz ^[1] ; Ozelin, Saulo Duarte ^[1] ; Reis Santos de Melo, Matheus ^[1] ; Guissone, Ana Paula Prado ^[1] ; Fernandes, Gabriela ^[1] ; Silva, Livia Mara ^[2] ; da Silva Filho, Ademar Alves ^[2] ; Tavares, Denise Crispim ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, Lab Mutagenese, Franca, SP - Brazil

^[2] Univ Fed Juiz de Fora, Fac Farm, Dept Ciencias Farmaceut, Juiz De Fora, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES; v. 83, n. 21-22 SEP 2020.
• Citações Web of Science: 2

Resumo

Licochalcone A (LicoA) is a flavonoid derived fromGlycyrrhizaspp. plants. The present study aimed to investigate the antioxidant, cytotoxic, genotoxic, and chemopreventive effects of LicoA inin vitroandin vivosystems. The results showed that LicoA (197.1 mu M) scavenged 77.92% of free radicals. Concentrations of 147.75 mu M or higher LicoA produced cytotoxicity in Chinese hamster ovary (CHO) fibroblasts. LicoA treatments of 4.43 to 10.34 mu M did not exert genotoxic activity, but at 11.8 mu M significantly lowered nuclear division indexes, compared to negative control, revealing cytotoxicity. Lower concentrations (1.85 to 7.39 mu M) exhibited protective activity against chromosomal damage induced by doxorubicin (DXR) or methyl methanesulfonate (MMS) in CHO cells. LicoA exerted no marked influence on DXR-induced genotoxicity in mouse erythrocytes, but reduced pre-neoplastic lesions induced by 1,2-dimethylhydrazine (DMH) in rat colon at 3.12 to 50 mg/kg b.w. Biochemical markers and body weight indicated no apparent toxicity. These findings contribute to better understanding the mechanisms underlying LicoA-initiated activity as a promising chemopreventive compound. (AU)

• Processo FAPESP: 17/06070-1 - Licochalcona-A, um flavonoide do alcaçuz: avaliação do potencial quimiopreventivo
• Beneficiário: Karoline Soares de Freitas
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 16/22863-9 - Estudo toxicogenético da licochalcona A e de sua influência sobre a instabilidade genômica
• Beneficiário: Iara Silva Squarisi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica